ID A0A1H1L034_9MICO Unreviewed; 816 AA.
AC A0A1H1L034;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=SAMN04489719_0310 {ECO:0000313|EMBL:SDR67650.1};
OS Agrococcus carbonis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agrococcus.
OX NCBI_TaxID=684552 {ECO:0000313|EMBL:SDR67650.1, ECO:0000313|Proteomes:UP000199649};
RN [1] {ECO:0000313|Proteomes:UP000199649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22965 {ECO:0000313|Proteomes:UP000199649};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; LT629734; SDR67650.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1L034; -.
DR STRING; 684552.SAMN04489719_0310; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000199649; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 3.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDR67650.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 22..474
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 446..473
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 816 AA; 87033 MW; D2B10D888F29266C CRC64;
MTATPAPPAS GDLVPSERID DVDVTSEMQD SFLEYAYSVI YARALPDARD GLKPVQRRIL
FQMSEMGLRP DKGHVKSARV VGDVMGKLHP HGDTAIYDAL VRLAQPFALR LPLVDGHGNF
GSLDDGPAAA RYTEARLAAA GLSLTDGLDE DVVDFVPNYD NSYQQPDVLP ASYPNLLVNG
ASGIAVGMAT NMAPHNLVEV VQAAKHLLAH PDATTADLMR HVPGPDLPGG GVIVGLDGIR
DAYEGGRGSF RTRARSSIER HGRKTQIVVT ELPYQVGPER VIEKIKDGVQ SKKLQGLSDV
QDLTDRKHGL RLVIGIKTGF DPDAVLQQLY RYTPLEDGFS INNVALVEGK PETLGLKGLL
RVYLDHRVSV VRRRSEYRLA RKRERLHLVE GLLIAILDID EVIQVIRSSD DSEQARGRLQ
EIFDLSEAQA EYILELRLRR LTRFSRIELE AERDELQAQI AELERILGSE SALHRVVADE
LDEVAERFGT PRRTLLTEAN GQQTTGRASA AKIAASLQIA DAPTTVLLSA TGRVVRVDGD
EPVPVPARRS RHDAIRSSVA TTTRGTFGLV TSSGAVLRLT PADLPSVPPA SVGLTAGIKV
KELGAFERGE EHVALIDLAS REPWLVATAN GTVKRIVPAD LRDRDRESVI ALKAGDRVVG
IAPAPDHAWI VLITSDAQLL RFPAAAVNPQ GAGAAGMKGI GLKADASVRF AGAVDEAAEV
VTVTAAAETL AGLDEPRVKV SAITEFPPKG RGTGGVQAHR LLKGEIGLAI AWAGPSPIAV
GADGSQRQLP PGGAPRAGSG VAIDGTIGAI GARLGA
//
