ID A0A1H1L1C3_9ACTN Unreviewed; 584 AA.
AC A0A1H1L1C3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Cell division protein FtsI (Penicillin-binding protein 3) {ECO:0000313|EMBL:SDR68326.1};
GN ORFNames=SAMN04489857_0616 {ECO:0000313|EMBL:SDR68326.1};
OS Parafannyhessea umbonata.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Parafannyhessea.
OX NCBI_TaxID=604330 {ECO:0000313|EMBL:SDR68326.1, ECO:0000313|Proteomes:UP000199480};
RN [1] {ECO:0000313|Proteomes:UP000199480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22620 {ECO:0000313|Proteomes:UP000199480};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; LT629759; SDR68326.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1L1C3; -.
DR Proteomes; UP000199480; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.770; -; 1.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:SDR68326.1};
KW Cell division {ECO:0000313|EMBL:SDR68326.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..224
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 269..570
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 61978 MW; 0540CB9867230FEB CRC64;
MTGASYDEAP RSRRGVPVRG GRAPQHSSYD QMVRIVFLVL GFILLFVVGR LIYLQVVDAK
YLSTRAAAQR TNEITIHAKR GTIYDRNGNV LATSEDCKTI YCNPQEVNDP AEAASVLADE
LGGEDTDYVD KLMGDNSFTY IKRQVDEDVA KSVQKKLDKK KIRGVYYLND VKRVYPYGAT
GGQVLGIVGT DGNGLSGLEL YYNDVLEGTD GKMMVETGSG GTPIAGGNSQ VVKKAKNGKD
IVISLDIDVQ KIAEDTIVQG VKDYKADSGS VMVTDPKSGE IIAACSTPLF NITDTSQIKE
GALNLKPVSS SYEPGSIFKV LTAAIGIDNG LVTPSSTFSV PGKVRVGDDL VGDDDGRTAT
MNMSLREILR RSSNAGMALV AQDVIGEEKF ANGVAKFKIG TKTGIDYPGE VKGIVKQLNQ
YDGASLGSMS FGQSLAIPLD QMVKAIGSIA NDGKIVTPHF LVSRGGKKVA WKSEGRAVSK
KTADEVTDMM RTVVKDGTAQ AAQVKGYDVA GKTGTGEQAD DSGKYVAFKY VSSLIGFANA
SDPKVLVYVG LNGTPYLATS SAAPLFSTIM SEALSDMGVT PDAG
//
