ID   A0A1H1LP92_9MICO        Unreviewed;       346 AA.
AC   A0A1H1LP92;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=tryptophan--tRNA ligase {ECO:0000256|ARBA:ARBA00013161};
DE            EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
GN   ORFNames=SAMN04489752_0187 {ECO:0000313|EMBL:SDR76378.1};
OS   Brevibacterium siliguriense.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC   Brevibacterium.
OX   NCBI_TaxID=1136497 {ECO:0000313|EMBL:SDR76378.1, ECO:0000313|Proteomes:UP000199597};
RN   [1] {ECO:0000313|Proteomes:UP000199597}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23676 {ECO:0000313|Proteomes:UP000199597};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363036}.
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DR   EMBL; LT629766; SDR76378.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H1LP92; -.
DR   STRING; 1136497.SAMN04489752_0187; -.
DR   OrthoDB; 9801042at2; -.
DR   Proteomes; UP000199597; Chromosome i.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00806; TrpRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002305; aa-tRNA-synth_Ic.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR002306; Trp-tRNA-ligase.
DR   NCBIfam; TIGR00233; trpS; 1.
DR   PANTHER; PTHR43766; TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43766:SF1; TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00579; tRNA-synt_1b; 1.
DR   PRINTS; PR01039; TRNASYNTHTRP.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363036};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363036};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363036};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363036};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363036}.
SQ   SEQUENCE   346 AA;  37734 MW;  A2F493805AC2F161 CRC64;
     MDSYSATLLR MPQLRSEVET QPDKFRMLTG ERPTGPLHLG HLFGSILERV SLQNRGVETF
     IVLADYQVIT DRDTSANVKN NVREAIMDYV SAGIDPTQTT IFTHSAVPAL NQLLLPFLSL
     VSDSELRRNP TVKSELAASE RPLSGLLLTY PVHQAADILF CKGNLVPVGK DNLPHVEITR
     TIARRFNERY GGVFREPEAM LTQTPELPGL DGRKMSKSYG NAIALGMSAD ETAAVIRKTQ
     TDSQRQITFA PERRPGVSAL LATAAVCTGA EPEDIASEVG ESGAGALKSL ATEAVNEYLA
     DHRARRRELE SDPTTVDRIL ADGNERANVI ADATLAEVRA AMGMDY
//