ID A0A1H1M5H7_9MICO Unreviewed; 352 AA.
AC A0A1H1M5H7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=SAMN04489751_0549 {ECO:0000313|EMBL:SDR81996.1};
OS Brevibacterium sandarakinum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC Brevibacterium.
OX NCBI_TaxID=629680 {ECO:0000313|EMBL:SDR81996.1, ECO:0000313|Proteomes:UP000199700};
RN [1] {ECO:0000313|EMBL:SDR81996.1, ECO:0000313|Proteomes:UP000199700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22082 {ECO:0000313|EMBL:SDR81996.1,
RC ECO:0000313|Proteomes:UP000199700};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; LT629739; SDR81996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1M5H7; -.
DR STRING; 629680.SAMN04489751_0549; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000199700; Chromosome i.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 22..341
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 352 AA; 37181 MW; 046DDABC38947C64 CRC64;
MTTEAAAPPS ETSVITSSHN RVGRIELNKP KLINALGQDM VGAIDDALKS WRNDDSITAV
LVTGRGERGL CAGGDIKAVY NDIVAGTDEN ARFWNREYKM NHAISEFPKP YVVIMNGITM
GGGVGISSHG SHRIVTDSTK IGMPETGIGL FPDVGGTHLL ANAPGELGTH LALTGQPVGA
GAALAMGLAD YYVLDADVPG LIAELEAGGD VEETITRHAS EAPENELAEA AAWINECYAA
DRAEDIVAAL AAHANPDANA AAKLIGTKAP TSVKVTLAAV RNAGNMSLAE VLEQDYRAAV
ALTRRPDLKE GIRAQVIDKD RNPQWSPATL YEVSDETVHE ILTTDHEEKV FA
//
