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Database: UniProt
Entry: A0A1H1MZ04_9ACTN
LinkDB: A0A1H1MZ04_9ACTN
Original site: A0A1H1MZ04_9ACTN 
ID   A0A1H1MZ04_9ACTN        Unreviewed;       312 AA.
AC   A0A1H1MZ04;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   13-FEB-2019, entry version 10.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=SAMN04489717_1023 {ECO:0000313|EMBL:SDR91848.1};
OS   Actinopolymorpha singaporensis.
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Actinopolymorpha.
OX   NCBI_TaxID=117157 {ECO:0000313|EMBL:SDR91848.1, ECO:0000313|Proteomes:UP000198983};
RN   [1] {ECO:0000313|EMBL:SDR91848.1, ECO:0000313|Proteomes:UP000198983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22024 {ECO:0000313|EMBL:SDR91848.1,
RC   ECO:0000313|Proteomes:UP000198983};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; LT629732; SDR91848.1; -; Genomic_DNA.
DR   BioCyc; GCF_900104745:BLU27_RS05050-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000198983; Chromosome i.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198983};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198983}.
FT   DOMAIN        8    187       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      202    279       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        180    180       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   312 AA;  33189 MW;  F01DE3C46D4FDE23 CRC64;
     MTEAARVRYA YLGPAGTFTE AALRTLPHLD RIDPEPCATV PAALDAVRSG TADGAVVPIE
     NSVEGGVPVT LDELAGGHLM ITREILLPVS FALLARPGTQ LADCKRISTH PHAAAQCRRW
     LADNLPQAEV TLASSTAAAA AAVAEEGSEF DAAVAPRIAG ERYRLDVLAN EIEDNADAVT
     RFVLATRPAA PGPMTGADKT SLVAFIRDDH PGALLEILDE FAVRGVNLTR IESRPTGDGI
     GRYNFSIDCE GHVDEARVGE ALMGLRRVCA EVRFLGSYPR ADGARIDLRI GTTDADFRGA
     ADWLARVREG RS
//
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