ID A0A1H1PGZ3_9FLAO Unreviewed; 614 AA.
AC A0A1H1PGZ3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Kef-type potassium/proton antiporter, CPA2 family {ECO:0000313|EMBL:SDS10295.1};
GN ORFNames=SAMN04487764_1459 {ECO:0000313|EMBL:SDS10295.1};
OS Gillisia sp. Hel1_33_143.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Gillisia.
OX NCBI_TaxID=1336796 {ECO:0000313|EMBL:SDS10295.1, ECO:0000313|Proteomes:UP000199552};
RN [1] {ECO:0000313|EMBL:SDS10295.1, ECO:0000313|Proteomes:UP000199552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hel1_33_143 {ECO:0000313|EMBL:SDS10295.1,
RC ECO:0000313|Proteomes:UP000199552};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; LT629737; SDS10295.1; -; Genomic_DNA.
DR RefSeq; WP_051931189.1; NZ_LT629737.1.
DR AlphaFoldDB; A0A1H1PGZ3; -.
DR STRING; 1336796.SAMN04487764_1459; -.
DR Proteomes; UP000199552; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004771; K/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR NCBIfam; TIGR00932; 2a37; 1.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00022538};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000199552};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..540
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 614 AA; 67639 MW; 27F01FFB6DCE9225 CRC64;
MSGSILFEAI VFLAAAIICV PLVKKLGLSS VIGYLLAGIL IGPYIFGFIG HEGEDILEFA
EFGVVMMLFL IGLEIQPSNF WKMRKIILGM GFTQVFGTML LTYLIFYALN LEWHISLTIA
MAVALSSTAI TLQTNKEKGL MNTSYGASSF SILLFQDIIV IIMLGLLPLL SEISTADTPV
VDASKAHENL LDNLPIGLQA LSIISSVVLI IFTGRYLIVP MLRLVAKTEV RELLVAAALL
IVVGISYVMG LVGLSPALGA FLGGVVLATS EFKHELESTL DPFKGLLLGL FFMAVGASIN
FRVIAEEPLL IAALVIGVIV VKASILYIVG LIFKLKLDQR LLLTVGLAQI GEFAFVLISF
AFQLNIFNQD QMDILLVVTA LTMTLTPILW IINERLVLPK IGTIESIKRP MDSIEQKHKV
ILLGFGHFGS TIGRFLRAHG VKTTVIEQNS NRVDFLRKMG FEVYYGDVSR LDLLESAGIA
EADFLISALD NPDLTPGLMK KLKSKYPDLK LMVRARNRDD AYKLHNIGID DIYRESLDTS
VKMASDLLFY MGFDAGATKE QADKFIKLDT ESLKRLAATP KDDKKYIFQA REEIAQQEKL
LVEDLKIGSS EIIK
//
