ID A0A1H1Q525_9ACTN Unreviewed; 447 AA.
AC A0A1H1Q525;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SAMN04489812_1141 {ECO:0000313|EMBL:SDS18474.1};
OS Microlunatus soli.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=630515 {ECO:0000313|EMBL:SDS18474.1, ECO:0000313|Proteomes:UP000199103};
RN [1] {ECO:0000313|EMBL:SDS18474.1, ECO:0000313|Proteomes:UP000199103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21800 {ECO:0000313|EMBL:SDS18474.1,
RC ECO:0000313|Proteomes:UP000199103};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; LT629772; SDS18474.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1Q525; -.
DR STRING; 630515.SAMN04489812_1141; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000199103; Chromosome i.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199103}.
SQ SEQUENCE 447 AA; 50161 MW; AAEDC16531304A5A CRC64;
MRINDLIGIG IGPFNLGLAS LTDPIEDLDA IFLEARDEFS WHPGMLLDEA TIQVPFLADL
VTMADPTSPY SFLNYLKQTG RIYPFYIRES FYPLRREYDA YCRWVCDQLR TLRFGQRVTA
VRYHPGHDAY QVIADHRGSE VQHWARRLAV GIGTEPWLPD AVGGLPGTVL HSSDYLHRKE
ELQQRPAITI VGSGQSAAEI YLDLLADIEQ HDYRLDWFTR SPRFFPMEYT KLTLEMTSPE
YTSYFHQLAA PLRAELLDQQ RGLYKGISSD LINAIYDTLY AKSVAGPPPT RLLTGVELVA
ANGAEAADGH ESELTLELHQ IEQGRRFTAK TSAIVCATGY RPRRPDFLEP IVDQIAIGAD
GRPDVARDYS VDGGRGRIFV QNGEEHTHGL SAPDLGLGAY RNSMIIAGIL GREVYPIERR
IAFQDFGVPA MSGPEPERVP HREELSA
//
