ID   A0A1H1QY57_9ACTN        Unreviewed;       397 AA.
AC   A0A1H1QY57;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
GN   ORFNames=SAMN04489716_0438 {ECO:0000313|EMBL:SDS28377.1};
OS   Actinoplanes derwentensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=113562 {ECO:0000313|EMBL:SDS28377.1, ECO:0000313|Proteomes:UP000198688};
RN   [1] {ECO:0000313|EMBL:SDS28377.1, ECO:0000313|Proteomes:UP000198688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43941 {ECO:0000313|EMBL:SDS28377.1,
RC   ECO:0000313|Proteomes:UP000198688};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LT629758; SDS28377.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H1QY57; -.
DR   STRING; 113562.SAMN04489716_0438; -.
DR   OrthoDB; 9780884at2; -.
DR   Proteomes; UP000198688; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd07385; MPP_YkuE_C; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR31302:SF0; TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN; 1.
DR   PANTHER; PTHR31302; TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198688};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        53..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          170..338
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   397 AA;  43150 MW;  635C1CA5B1884D34 CRC64;
     MLALMSVGET VDTEPRKRGP RVARFGVVLV AVIALLFGVP WATLVWSGND WPLPVFVAGT
     LLFAAVAGVF PWLMFRGHGG HRDRESRIAD TLLGVAWVLF VWSIIGQLLG LLLLAAGVDG
     PLRSRVVSAF VVILSTVLLA WGHHEAMRVS RVRRVDVTIP RLGKGLDGLT VALITDTHYG
     PINRAAWSRG VTEVVNSLDA DIVAHTGDIA DGLVDQRLEM AAPLGEIRAR FARVYVTGNH
     EYHSGAQGWV EHMEHLGWET LHNRHVLVTR GGDSLIVAGV DDRTAGGSGL PGHRTDHEAA
     LSGTDPDLPV LLLAHQPQQI TDAVKHGIDL QLSGHTHGGQ MWPFHYLVLT DQPSLQGLSR
     HSDRTQLYTS RGTGFWGPPF RIFAPSEITL LTLRATA
//