ID   A0A1H1R3G4_9MICO        Unreviewed;       860 AA.
AC   A0A1H1R3G4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Glycine cleavage system T protein (Aminomethyltransferase) {ECO:0000313|EMBL:SDS30222.1};
GN   ORFNames=SAMN04489751_1705 {ECO:0000313|EMBL:SDS30222.1};
OS   Brevibacterium sandarakinum.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC   Brevibacterium.
OX   NCBI_TaxID=629680 {ECO:0000313|EMBL:SDS30222.1, ECO:0000313|Proteomes:UP000199700};
RN   [1] {ECO:0000313|EMBL:SDS30222.1, ECO:0000313|Proteomes:UP000199700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22082 {ECO:0000313|EMBL:SDS30222.1,
RC   ECO:0000313|Proteomes:UP000199700};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
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DR   EMBL; LT629739; SDS30222.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H1R3G4; -.
DR   STRING; 629680.SAMN04489751_1705; -.
DR   OrthoDB; 2055370at2; -.
DR   Proteomes; UP000199700; Chromosome i.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:SDS30222.1};
KW   Transferase {ECO:0000313|EMBL:SDS30222.1}.
FT   DOMAIN          13..383
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          387..441
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          444..727
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          752..852
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   860 AA;  93006 MW;  C1481731AE9588C7 CRC64;
     MPISSPSSPS SPRVVIIGAG IVGANLADEL AQLGWTNTLV LEQGPLNIPG GSTSHAPGLV
     FSSNGSKSMT EFAQYTIEKL TSLTGSDGRG SFLPVGGLEI ATQEDRLQDL HRRAGWNRSW
     GVDAEVVDAQ ECLRLFPMLG PDKVLGGLLT PGDGLALAAR GTQLVMDRAR AAGVEFRDRT
     TVTGIEQSGG KVTAVLAGDD RFPADIVVSC AGFWGPNIGA MVGTTIPLLP LGHQFAWTTE
     VPSLAGKNEQ PARASAPILR YQDKDLYYRE WGERIGIGSY AHRPMPVDLD TLRTYSPDEI
     TDEVMPSSLD FTPEDFAREW EATKELLPEL AQTQVQRGFN GIFSFTPDGG SLVGQSREVD
     GFFVAEAVWV THGAGIARAV AELIALGRSN TDLSGIDLNR FEDALTTPEY VSETSQQNFV
     EIYDVIHPLQ PRVSPRDLRL SPFNDRQKEL GAFFLETNGW ERPHWYEANA SLLEELPEEW
     KAPKREGWAD MFHSPIAAVE AWKTRTNVAM YDMTALKRFE VKGPGAGELL HGLTTSSMLR
     KPGAVSYTLL LDDEGGITSD ITVAILDEQT YQVGANSNID FATITRAARE QSTADPSKWA
     TVRETTQGTC CIGLWGPLAR EVISQVSNDD LSNDGLKYFR TKQITIGGVP VTAMRLSYVG
     ELGWELYTSA DLGHRLWDVL WEAGREFGLI AGGREAFNSM RLEKGFRSFG SDMTSEHEPV
     QAGLGFAVKA SKTDDFRGKA ALESRAAAAT TKLTCLTLDR REDVVLGSEP VYVAGGSAGR
     TDAAGSDHGA SGAVNRSGKA DGYVTSAAYG YSIGQTIAYA WLPNTLSVGD GVEIEYLGRR
     LPATVTAEPI FDPEMTRLKG
//