ID A0A1H1SR41_9CORY Unreviewed; 447 AA.
AC A0A1H1SR41;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SAMN04488539_1791 {ECO:0000313|EMBL:SDS49849.1};
OS Corynebacterium timonense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=441500 {ECO:0000313|EMBL:SDS49849.1, ECO:0000313|Proteomes:UP000182237};
RN [1] {ECO:0000313|EMBL:SDS49849.1, ECO:0000313|Proteomes:UP000182237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45434 {ECO:0000313|EMBL:SDS49849.1,
RC ECO:0000313|Proteomes:UP000182237};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005102}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; LT629765; SDS49849.1; -; Genomic_DNA.
DR RefSeq; WP_019193961.1; NZ_LT629765.1.
DR AlphaFoldDB; A0A1H1SR41; -.
DR STRING; 1203190.GCA_000312345_01126; -.
DR eggNOG; COG3486; Bacteria.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000182237; Chromosome i.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000182237}.
SQ SEQUENCE 447 AA; 49667 MW; 6D47534C671DBAFB CRC64;
MPTPHTTDTN RTVDIAGVGI GPFNLGLAAL AQPLVSAGEL TAAFFDRRPA FRWHPGLLLE
ESTIQVPFLA DLVTLADPTS QFSFLNYLKL KGRLHRYYIR EDFFPLRSEY SDYCAWVSEQ
LSTTHWGHDV RAVRPAPEQL RAATGARWVV EIDGQPDVFA RNVVSGVGTD PYVPEDLAGA
LLASDSPRAI HSADYLPARA WLRQAESVTV IGSGQSAAEI YADLLGQAVA NGTRVDWITR
SPRFFPMEYT KLTLELTSPE YARYVRGLPM DQRDRRVRED RSLYKGISSE TVNAIYDMLY
RLSLSYDLAE HTTLRAGVSV RYARTRGDAL EFDLRHDESG TQATHTTHAA ILCTGYRSAQ
IPAFLEPARD LINLDPKGRF DLNENFAADD EGSLFALNAD EHLISLNGPD LGMGPWRNSI
VLRAITGREV YPIERSIAFQ DIGGFGA
//
