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Database: UniProt
Entry: A0A1H1T8M6_9MICO
LinkDB: A0A1H1T8M6_9MICO
Original site: A0A1H1T8M6_9MICO 
ID   A0A1H1T8M6_9MICO        Unreviewed;       327 AA.
AC   A0A1H1T8M6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   13-FEB-2019, entry version 10.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=SAMN04489751_2307 {ECO:0000313|EMBL:SDS56572.1};
OS   Brevibacterium sandarakinum.
OC   Bacteria; Actinobacteria; Micrococcales; Brevibacteriaceae;
OC   Brevibacterium.
OX   NCBI_TaxID=629680 {ECO:0000313|EMBL:SDS56572.1, ECO:0000313|Proteomes:UP000199700};
RN   [1] {ECO:0000313|EMBL:SDS56572.1, ECO:0000313|Proteomes:UP000199700}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22082 {ECO:0000313|EMBL:SDS56572.1,
RC   ECO:0000313|Proteomes:UP000199700};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; LT629739; SDS56572.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000199700; Chromosome i.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199700};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN       20    204       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      219    296       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        197    197       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   327 AA;  34600 MW;  C95A057934BE3FF9 CRC64;
     MSTEQASPEQ ASPEQVGTER FAYLGPEATF TEAALLKYLD KQGLRTTARS QPMRNAVAAL
     DSVLDGECSA AVVPIENSVE GGVPATIDAL TDHGRLQIVA EVVVPVRFVL AVKPGTDPHT
     LTSFGSHPHG EAQVRTFMSA NFPDAVYLPT SSTAAAARDL ANDAADHVAA VCPALAAERY
     GLEILADDIG ERQDAETRFV VVTRPGTIPA PTGSDKTTVV ASLRSDRAGA LLEMLEQFSS
     RGVNMSRIES RPTGGGLGLY QFSIDLLGHV HEARMADALQ GVHRVTRNLR FLGSYPSASK
     NTVPLDPTTT DDSFAAATAW LDSTLNG
//
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