ID A0A1H1TTB0_9ACTN Unreviewed; 567 AA.
AC A0A1H1TTB0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN04488570_2326 {ECO:0000313|EMBL:SDS63448.1};
OS Nocardioides scoriae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=642780 {ECO:0000313|EMBL:SDS63448.1, ECO:0000313|Proteomes:UP000198859};
RN [1] {ECO:0000313|Proteomes:UP000198859}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22127 {ECO:0000313|Proteomes:UP000198859};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; LT629757; SDS63448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1TTB0; -.
DR STRING; 642780.SAMN04488570_2326; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000198859; Chromosome i.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SDS63448.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDS63448.1}.
FT DOMAIN 24..248
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 299..529
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 542..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 59487 MW; 99BA9C1D0E58CF55 CRC64;
MTKQNTPSTS AAGTAAAGRP VKWVSFVGSG PGDPGLLTVR AVELLREAEV VVTEIPDHEA
LVRSVLGLPA PVEAAEATGD EAAAVEPEGP VFVDGGFGED GQPLTHAARA KVVVRQAKTG
RRVVRLLSGD PFLYASGPEE ALACTKADVG FEIVSGVSSV TAVPAYAGIP LTTKNHREVA
VVTCSDAKVD WSAYAAHPTL VLLSAVGAIG EIADELVAAG RSVDTPVSMT RTGTLTTQET
VVSTLGQIAA DARAAGMTPP AVTVVGAVVE QRDALSWFET KPLFGWRVLV PRTKEQAGAL
SSRLRGHGAT PEEVPTISVE PPRNPLQMDK AVRGLVEGRY EWIAFTSVNA VRAVREKFEE
YGLDARAFSG LKIAAVGEKT AASLSDWGLK ADLIPSGEQS ARGLLEDWPP YDDVLDPINR
VFLPRADIAT ETLVAGLVEL GWEVDDVTAY RTVRAAPPPA PTREAIKTGK FDAVVFTSSS
TVRNLVGIAG KPHTSTVIGV IGPATAKTAE EHGLRVDVMA SEPSVESLVD ALADFGAARR
SSLLESGQPV TKPSDRRPST RRKASSK
//
