ID A0A1H1U7E4_9ACTN Unreviewed; 942 AA.
AC A0A1H1U7E4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Multisubunit sodium/proton antiporter, MrpA subunit /multisubunit sodium/proton antiporter, MrpB subunit {ECO:0000313|EMBL:SDS68364.1};
GN ORFNames=SAMN04489716_1355 {ECO:0000313|EMBL:SDS68364.1};
OS Actinoplanes derwentensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=113562 {ECO:0000313|EMBL:SDS68364.1, ECO:0000313|Proteomes:UP000198688};
RN [1] {ECO:0000313|EMBL:SDS68364.1, ECO:0000313|Proteomes:UP000198688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43941 {ECO:0000313|EMBL:SDS68364.1,
RC ECO:0000313|Proteomes:UP000198688};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; LT629758; SDS68364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1U7E4; -.
DR STRING; 113562.SAMN04489716_1355; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000198688; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..104
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 121..411
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 595..658
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 669..751
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 789..911
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 942 AA; 97209 MW; 7F2E8C79D9C7ACF0 CRC64;
MLILLGAHLI AAVLAPALVR LLGPRAFYLL ALVPLAVFGW AITNVGGPPQ EWIHPWVPDL
GLALALRVDT LSWLLVSLVG GVGALVLAYC ARYFSAGEPG LGRFAAVFVG FAGAMLGLVV
SDDLLLMYVF WELTTVFSYL LIGHNGTGRP GRRAALQALI VTTAGGLAML VGIVILGQHA
GSYRWSEMST ALPGGTPLVV AVVLILAGAL SKSAIFPISF WLPAAMAAPT PVSAYLHAAA
MVKAGIFLVA RFAPAVVAAG GTAAVTWQAL SVGLGLVTML LGGWAALFQH DLKLLLAYGT
VSQLGLLTVV LGFGTPEMAL AGVAMLLGHA LFKAALFLIV GVVDKTTGTR DLRQLNGLGR
RAPVLLAAAV LAAASMAGLP PAIGFVGKEA VFAALLDSGT TGWIVLAGVL AGSVLTVAYT
TRFLWGAFAD KSTEGGERTE PTPAGSLLVA PVVLAVAGIA AGVGAGIVDE VLSPYPSMFG
NGPATAHLAL WHGLGVPLLL SVSVLAGGLA VFRLMPAGKA GPKPGGGVYE RIMTGMDRLA
VEVTGATQRG SLPFYLATIL LVLIATAGPA MIAGWPSGSE FRLWDTPLHL LPVAVSVVAA
VFAVPARRRL TAVILVGVTG YANAGIFLLH GAPDLALTQF LVETVTLVMV MLVLRRLPSH
FSQRPGSWRR RVRVGIGVAV GTVMAGVGYL AVSARQAIPV SVDYPELAVT YGGGHNIVNV
ILVDIRAWDT MGEIAVLVAV ATGVASLIFR HAGELHRRGP VGTPSDPPAG EPVWLMAGHT
VEAGRRSTML EVVTRLLFHA IILLSVYLLF TGHDTPGGGF TGGLVAGLAL TVRYLAGGRY
ELAAAAPVDA GAVLGAGLLI AVGTGVGALV LGGQVLQSAI VDLQIPLLGH LHLVTSALFD
IGVYLIVIGL VLDVLRSLGA EIDRHAQPTV HDHEKRPQEE LV
//
