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Database: UniProt
Entry: A0A1H1ULL5_9ACTN
LinkDB: A0A1H1ULL5_9ACTN
Original site: A0A1H1ULL5_9ACTN 
ID   A0A1H1ULL5_9ACTN        Unreviewed;       564 AA.
AC   A0A1H1ULL5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SAMN04489812_2819 {ECO:0000313|EMBL:SDS72709.1};
OS   Microlunatus soli.
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Microlunatus.
OX   NCBI_TaxID=630515 {ECO:0000313|EMBL:SDS72709.1, ECO:0000313|Proteomes:UP000199103};
RN   [1] {ECO:0000313|EMBL:SDS72709.1, ECO:0000313|Proteomes:UP000199103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21800 {ECO:0000313|EMBL:SDS72709.1,
RC   ECO:0000313|Proteomes:UP000199103};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; LT629772; SDS72709.1; -; Genomic_DNA.
DR   Proteomes; UP000199103; Chromosome i.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199103};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199103}.
FT   DOMAIN      255    383       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      467    536       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     263    270       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   564 AA;  63050 MW;  357945C66F09DDBC CRC64;
     MTEESPHQPG ADNLAEQVTL AWNRVRTELT PEQRIWLNDS KPLTLHENTL MVAVPSEFTR
     QRLETRYRDS IEAALGSHFQ RPTKVAVIVD KSLVPDDADG APDRSLPAAG DTVQRAGQNG
     DLRSHDGRDP GYDEPTFTQR DFQGGEYGPS TDGSENGIRD GSYATAEYSP SGYREPRGYG
     ASDQLHGRAD YPPEGPLSPT PLSPTPRPDT DGADRSRRED SRLNPKYSFE TFVIGGSNRF
     AHAAAVAVAE SPGKAYNPLM IYGDSGLGKT HLLHALGHYV RNYFSRARVR YVSTEELTND
     FISAITDNKT HQFRRKYRDV EVLLVDDIQF LEGKEQTQEE FFHTFNTLHN AQKQIVMTSD
     RPPKLLDSLE ARLRSRFEWG LITDIQPPDL ETRIAILRKK AAQERLTAGP DVLEFIASKI
     QTNIRELEGA LIRVTAFASL NRQPVDMSLA EVVLKDLIPE GGEAQITSGT IMGQVSSYFG
     LTIDDLCGQS RTHVLVTARQ IAMYLCRELT DLSLPKIGQQ FGGRDHTTVM HAERKIRTLM
     AERRSVFNQV TELTNRIKQQ SARG
//
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