ID   A0A1H1VWW0_9MICO        Unreviewed;       920 AA.
AC   A0A1H1VWW0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=SAMN04489752_2782 {ECO:0000313|EMBL:SDS89205.1};
OS   Brevibacterium siliguriense.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC   Brevibacterium.
OX   NCBI_TaxID=1136497 {ECO:0000313|EMBL:SDS89205.1, ECO:0000313|Proteomes:UP000199597};
RN   [1] {ECO:0000313|Proteomes:UP000199597}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23676 {ECO:0000313|Proteomes:UP000199597};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; LT629766; SDS89205.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H1VWW0; -.
DR   STRING; 1136497.SAMN04489752_2782; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000199597; Chromosome i.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          9..462
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          785..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..920
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   920 AA;  98428 MW;  8630D7E609AEAB9F CRC64;
     MPEGRVIEVD VSSEMESSFL EYAVSVIHSR ALPDARDGLK PVQRRIVYQM GDMGLRPERG
     HVKSSRIVGD VMGKLHPHGD TAIYDALVRL SQGFIMRVPL VDGHGNFGSL DDGPAAPRYT
     EARLTTAAMQ MIAGLDEDVV DFVPNYDNTL TQPEVLPSAF PNLLINGASG IAVGMATNMA
     PHNPGEVIAA CAHLIRNPEA GLSELMRFVP GPDLPTGGRI IGLDGVREAY ETGRGTFRTR
     ATVSIENISA RRKGIVVTEL PYLVGPEKVV SKVKDAVGAK KLTGIASIDD YSDRKNGMRL
     VIGVKNGFNP EAVLAELYRQ TPLEESFSIN NVCLVEGQPR TLGLRELLMV YLSHRIDVVR
     RRTVFQLRKA KDRLHLVEGL LIAILDIDEV IQLIRSSDDA AAARTRLMDV FELSELQATY
     ILDLQLRRLT KFSRLELEAE RDELKKKIDY LESLLADEAK LRELVASELE STAEIIGSPR
     RTVLIEGSMK ELSAKGKKAP ANLRIADSPC RVLLSTSGRI ARTSDVAALA REGRRSSHDA
     LVSEIVTTTQ GKVGAITTTG RLHMVDVVDL PALPPAAARP NVAGGVKIAE YTALEKNEKI
     IGLVDLDREF VLGTADGVVK RVSVAGRPNK NEWEAITLKG KDSVVGVAQL EDIDDSLAVF
     VTSNAQLLAF DASGLRAQGW NASGVAGIKV AAEAKVIFFG MTPKAAKTDE DGAADAELGS
     FAVVTIASGE NFYGAPSSSI KVSEFSEFPT KGRATSGVRA HKFLKGETEL SLAWVGDSPQ
     AAATAGGART LPAELSRRDG TGSPLESKID VIGTLPRLGG AESADHSQTA VDDSADASDG
     AEATADSATG TDTKTAKSGK KRSSGKAARG QQGLATNLDE LNLDLDEAKD EIARSKFDTE
     SAVIVSHDDD DDGDDDSALF
//