ID A0A1H1X7A6_9ACTN Unreviewed; 859 AA.
AC A0A1H1X7A6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Polynucleotide kinase-phosphatase {ECO:0000313|EMBL:SDT04980.1};
GN ORFNames=SAMN04489812_3952 {ECO:0000313|EMBL:SDT04980.1};
OS Microlunatus soli.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=630515 {ECO:0000313|EMBL:SDT04980.1, ECO:0000313|Proteomes:UP000199103};
RN [1] {ECO:0000313|EMBL:SDT04980.1, ECO:0000313|Proteomes:UP000199103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21800 {ECO:0000313|EMBL:SDT04980.1,
RC ECO:0000313|Proteomes:UP000199103};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LT629772; SDT04980.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1X7A6; -.
DR STRING; 630515.SAMN04489812_3952; -.
DR OrthoDB; 9807890at2; -.
DR Proteomes; UP000199103; Chromosome i.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07423; MPP_Prp_like; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041780; MPP_PrpE-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR024028; PNKP_bac.
DR InterPro; IPR032380; PNKP_ligase_dom.
DR NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR PANTHER; PTHR42850:SF7; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE PRPE [ASYMMETRICAL]; 1.
DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF16542; PNKP_ligase; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000313|EMBL:SDT04980.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199103};
KW Transferase {ECO:0000313|EMBL:SDT04980.1}.
FT DOMAIN 182..385
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 471..854
FT /note="Polynucleotide kinase-phosphatase ligase"
FT /evidence="ECO:0000259|Pfam:PF16542"
SQ SEQUENCE 859 AA; 94127 MW; 9D693C6EC80580CC CRC64;
MSTRVEIPRL ALVVLIGVSG SGKSTFAADH FAPFETISSD FCRGLVSGDE NDQASSADAF
DVLAYIAGKR LAAGRLTVVD ATNVTRETRR QFVQLARDHD VLPVAVVLDT PVGTAIERNA
SRQSRDFGAR VVKRQHDQLR RSLKGLGKEG FRTVHVLTPE QAADAEIIRT RLLNDRRDDH
GPFDVIGDVH GCRSELESLL DKLGYRIIRD VQGRAVDAEH PDGRRALFLG DLVDRGPDTP
GVLRLAMGMT AAGHAVAITG NHEHKLVRAL APRRGRSGKQ QPNTAHGLQQ TLDQLAAEPA
EFVDRVTTWC RDLIAHLVLD DGKLVVAHAG LKESYHGRAS GRVRSFALYG DTTGEIDEFG
LPVRLPWAED YRGSATVLYG HTPVPDAVWL NNTLCLDTGC VFGGRLTALR YPENEIVDVP
AEQVWCEPAK PFGSVQRTGD DLQLGDVLGR RVIETVQHGR ITIGEDQAAG AFEVMTRFAL
HPRWLGYLPP TMAPAAATDR DDHLEFPDTA FAEYADAGVR SVICEEKHMG SRAVIMVCAD
EAAARRRFGD QDERGGGRTG VVHTRTGRAF AGPAQTEELL GRLRAAIGAA GLWQQLGADW
LLLDAEILPW SLKADALIRE QYAATGAAGR MMLPAVRDRL RAAADRGLDL GGLDSRIDRR
LAAIDDFSAA YRPYQWPTDG WGGVQVAPFQ LLASGSTDGA ATYETRDHGW HLELADRLHA
VDAELVRSTR RLSVRTDDPD SVAAGIDWWT ELTATGGEGM VVKPFPNLTR GSKGLVQPGL
KVRGRQYLRL IYGPDYLEPV ELARLKKRNL GHKRSLALRE YALGLESLRR LTTDEPLWRV
HETVFAVLAL ESDPVDPRL
//
