ID   A0A1H1YGE4_9ACTN        Unreviewed;      1608 AA.
AC   A0A1H1YGE4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Diguanylate cyclase (GGDEF) domain-containing protein {ECO:0000313|EMBL:SDT20464.1};
GN   ORFNames=SAMN04489716_2842 {ECO:0000313|EMBL:SDT20464.1};
OS   Actinoplanes derwentensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=113562 {ECO:0000313|EMBL:SDT20464.1, ECO:0000313|Proteomes:UP000198688};
RN   [1] {ECO:0000313|EMBL:SDT20464.1, ECO:0000313|Proteomes:UP000198688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43941 {ECO:0000313|EMBL:SDT20464.1,
RC   ECO:0000313|Proteomes:UP000198688};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; LT629758; SDT20464.1; -; Genomic_DNA.
DR   STRING; 113562.SAMN04489716_2842; -.
DR   OrthoDB; 9772100at2; -.
DR   Proteomes; UP000198688; Chromosome i.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198688}.
FT   DOMAIN          1..256
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          1475..1608
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
SQ   SEQUENCE   1608 AA;  174465 MW;  E8F6184EFB1029AE CRC64;
     MQAATTDELY RTARTSVQRR WNDDRTTTIR KVLSGPGAAR RAAQEKALLE RLAGVAGVSQ
     TTDEPVGVDT VAMVDVGGVT LRARPMPLAV EPAITLMTQL IEIVAEVHRR GVVHKDINPD
     NILIDRSGRP VLIDFDIAST FAQEQPGFVH ENEIAGTLPY LAPEQTGRTG RLVDQRADLY
     GLGTTMYELL TGRPPFGSAD RDPLELLHDH LARVPARPDQ VEPAVPAVLA DVVMRLLAKE
     PDQRYQSADG VLHDLRRIRD GDLSAFPLGE RDFPQRIAPP SRLVGRETEI AALHTAFDEC
     LVGRARGVLV SGAPGVGKTA LIDELRTVAT VGGGWLVSGK FDQYRRDTGA DAMWQALGGI
     ARFLLAEPEQ TLSTVRADLL RALGVNAGIL AAQLPQFQAL LDVEPEHSLA DPAKTQPRLV
     QTALELLRVV AHPAQPVVIV VDDLQWAGAP TIDLIDALLL DAGLRGVLLV GAYRQAEVDQ
     THPLAAMFSR WENSTLAPRQ LRLENLRPVD QCVLVGDILR LEPQQAQRLA VEIDTRAHGN
     PFDTVELINA LRTDGILLCD EHGWHWDPAE LRGHVRDGDV LDVLTARIDR LPATTGELLT
     IMACLGGEVG LRVLVAAAAR PGTDVEADLQ PALEDGLLVM SREDETLRFR HDRIQQAAFA
     RGAAALHLPV ARRLLAEPGL AGLAAEQYLA ADAAFEDGAE RARVALLYWE AAGGARLSSN
     QVLRERYLRA AQSLVDATDT ETLADLVAEH HAVLYTLGRL DEADDAFAWL SRHRPEPLAN
     ADSVCLQIAS LTIRLRPHDA VTLGLTALRG LGLGLPTPER LDAEIDDGID GLYRWLAGST
     VEEEMRRPEP TDPLLRAQAR IFNRTIPPAF FSGQIPVMAW MVGRAAGMWA AHGPSAALVG
     PLAHIGFVII PMRDDHAAAN QALGRVLAVS EDRGWEPDTS QCRFLFALTC GHWVQPLEQS
     LRQARLAREG LIRAGEQLNA AFTFYVTAPN ALDCTPTIEG FRTVIDDAIS FASRTGNDHI
     ATMLLPYRQI VRALCGQTES GLDDSSFRHT TYLTEMAPNP TAVGFHQIVR GVLGLITGDL
     ALVADAIAGA RKVEDYAEVN YVKVLSGLLL GIDCAERLRR SDSPSPGLLA ELDRQRAWMS
     ARAAQIPENT LHLAHLLDAE RAWAVGDLAA AIAGYDAARE AVNQVERPWH RAVIAGRAAE
     FHTAHGAPLL ALHLRAECWR TLTRWGATGV AARLAADWPA VADVDRTATA SSSRADSLDL
     LAVVRAGQAL SGETDLTRLR ERVGDVLGAL AGADRVLMAV PDETTGDWLL PDPGGVPISL
     AEAGARGLLP LAAVRYAQRT GEPLTIDDVT SHELCTRERY VDTHQRSSLL IVPIISHGTQ
     RAMLVLENSL ARGAFTVSRL EAVQLIAGQL TVAIDNALLY ASLERKVAER TEALEHANHQ
     LEVLTVTDAL TGLFNRRHLE DSLETEWRRR LRSGLPLAIA MLDVDHFKRY NDEYGHQAGD
     ECLRRVAATI GANIRSTDIA ARYGGEEFCI VMADTDLDAA VVAAERVRFT VAALDIEHSG
     SLSGRVTVSI GVAAEVPRPD ALPEFLLKAA DTALYDAKNG GRDRVARH
//