ID A0A1H1YPQ0_9ACTN Unreviewed; 630 AA.
AC A0A1H1YPQ0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Sodium/proton antiporter, CPA1 family {ECO:0000313|EMBL:SDT23443.1};
GN ORFNames=SAMN04488543_3391 {ECO:0000313|EMBL:SDT23443.1};
OS Friedmanniella luteola.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Friedmanniella.
OX NCBI_TaxID=546871 {ECO:0000313|EMBL:SDT23443.1, ECO:0000313|Proteomes:UP000199092};
RN [1] {ECO:0000313|EMBL:SDT23443.1, ECO:0000313|Proteomes:UP000199092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21741 {ECO:0000313|EMBL:SDT23443.1,
RC ECO:0000313|Proteomes:UP000199092};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR EMBL; LT629749; SDT23443.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1YPQ0; -.
DR STRING; 546871.SAMN04488543_3391; -.
DR Proteomes; UP000199092; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199092};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 115..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 307..328
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 349..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 376..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 547..630
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
SQ SEQUENCE 630 AA; 67542 MW; 3D63C520F7EF4234 CRC64;
MARVDTAIGI CAIVASVLVV TAVADRLRFP APLLLMLVGI GASFVPFIDE PELTPELVLL
GFLPPLLYAT AIRSSIIDFR THRRPIAFLS VLLVVITALG IGLITWLLLP VPFAVAFALG
AVVAPPDAVA ATSIARRIGL PRRVITLLEG ESLLNDATAI TCLRVALVAI AGAVSAWEIG
LGFVIAVAGA LIGVGVAALA VVIRRHVHNP VFDTAISLLV PFVAYLPAEA LHYRDFHGSG
VIAVVTAGLV LGHKSPVIQS GQSRLAERVN WATIQFLLEN TVFLLIGLQA RRIVEALSTS
TLSGGQIALF VAAVLVGVIV LRLVWVTISR FLIYRVDRET GEGRPPWSHT IVVGWAGLRG
VVTLAAAFLI PEDVEHRAVL IFAAMVVTAG TLLIQGLTLP ALVRVLKMRG PDARSDALQA
ATVLTTAGNA GLAALDRLAG PEDEASAVQL VRDRISSRSD ALWEKLGTGR DAGETPAEQY
RRLRLGAMRA ERDEVLRVRS SGTVDHDVVE QVLASFDIEE SMLTIATERV DRLSENQSVA
TPLDPSGSCV HLDTAPADVE PRSEVCLDCV REGTRSVHLR RCLACGNVGC CDSSVGRHAE
RHFHTSHHPV MRSHEDGESW RWCYLDERLG
//
