ID A0A1H1YY98_9ACTN Unreviewed; 827 AA.
AC A0A1H1YY98;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04489812_4861 {ECO:0000313|EMBL:SDT26444.1};
OS Microlunatus soli.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=630515 {ECO:0000313|EMBL:SDT26444.1, ECO:0000313|Proteomes:UP000199103};
RN [1] {ECO:0000313|EMBL:SDT26444.1, ECO:0000313|Proteomes:UP000199103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21800 {ECO:0000313|EMBL:SDT26444.1,
RC ECO:0000313|Proteomes:UP000199103};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LT629772; SDT26444.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1YY98; -.
DR STRING; 630515.SAMN04489812_4861; -.
DR Proteomes; UP000199103; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDT26444.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199103};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 609..820
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 827 AA; 88166 MW; 256ED46055642BCE CRC64;
MKGRLRVLLG AAPGVGKTYT MLEEGRRLRA EGRDVVVAFL ETHGRAATAA MADGLEILAR
RSISHRGVEL TELDTAGVIA RRPDIALIDE LAHTNAPGSA NPKRWQDVQD VLDAGIDVIS
TLNIQHIESL NDVVEKITGV PQRETIPDAV LRTADQTEVV DLAPQALRDR LAGGNVYPAE
RIDAALSNYF RIGNLTALRE LALLWLADEV DQALQHYRAE HGIDTTWEAR ERVVVTLTGG
PEGDTLIRRA ARIAARSSGG ELLAVHVTSH DGLRAGNPGT LLKQRALLEE LGGSYHQVLG
EDIPRALVDF AKAVNATQLV IGVSRRSRLV AALTGPGIGA TVTREAGNID VHVVNHAAAG
GRVRLPRIGG ALSLRRRVVG LILALFGGPL LTWFPVTVRS TDTITSDVLS YQLLVVVVAL
IGGIWPAAFA AVMSGLTLDY FFVEPYNTIT VDEPAHLLAL TLYVIIAGLV SFVVDRAARQ
TRAARRSAAE ADLLATTAGS VLRERDALHA LVARTREAFN LNGVKLSADA IVLAADGDMS
AELTEKIGVG TRATLQLYGP PIEAANRRLL SAIITQIEAA IQHRDLAATA REVAPLAASD
RIRSALLTAL SHDLRRPLAA ATAAVGGVLH TGNSLSDSDR TELLQTADES LTTLTRLITD
LLDVSRVQAG ALTVTLTSVD PADAILPAVD ELRLTPREAE LDLQPNAVRA DPVLLQRVIV
NLLTNAIRHT PPNTPIRVST SAFGDRVEIR IIDHGPGIPA DRRDEVFLPF QRQGDTDNTT
GLGLGLALAK GFTETMHGNL SIEDTPGGGV TMVLSLPADA TDRTPAP
//
