ID A0A1H1ZKZ0_9BACL Unreviewed; 901 AA.
AC A0A1H1ZKZ0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SDT34289.1};
GN ORFNames=SAMN05444162_3898 {ECO:0000313|EMBL:SDT34289.1};
OS Paenibacillaceae bacterium GAS479.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae.
OX NCBI_TaxID=1882832 {ECO:0000313|EMBL:SDT34289.1, ECO:0000313|Proteomes:UP000198637};
RN [1] {ECO:0000313|EMBL:SDT34289.1, ECO:0000313|Proteomes:UP000198637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS479 {ECO:0000313|EMBL:SDT34289.1,
RC ECO:0000313|Proteomes:UP000198637};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Counteracts the endogenous Pycsar antiviral defense system.
CC Phosphodiesterase that enables metal-dependent hydrolysis of host
CC cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC {ECO:0000256|ARBA:ARBA00034301}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic CMP + H2O = CMP + H(+); Xref=Rhea:RHEA:72675,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58003,
CC ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00034221};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72676;
CC Evidence={ECO:0000256|ARBA:ARBA00034221};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:184387; Evidence={ECO:0000256|ARBA:ARBA00034227};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576;
CC Evidence={ECO:0000256|ARBA:ARBA00034227};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LT629764; SDT34289.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1ZKZ0; -.
DR STRING; 1882832.SAMN05444162_3898; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000198637; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198637};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..225
FT /note="DUF4131"
FT /evidence="ECO:0000259|Pfam:PF13567"
FT DOMAIN 270..537
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 628..852
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 901 AA; 98221 MW; 43BC55D04BD0609B CRC64;
MDLAGDEGCQ IDPREGGMRL EARGWLDGRP LVWAAVCFVA GSSAAAYWSP GGMLAAGLGL
GLLLAALALA GQARYGLAAA CLAAYALAAG ERLWADARSQ TALSALYAAA EAQLEPPELR
VEAAGTVVSP VEFDGDLVQL RLEAHSLRAG DAQQAKPLRE TLLVRVKLLH EQELAAAKAW
RRGNSVRLRG TLELPAPPAN RGGFDYRRYL RSQGITWLLQ VQGAGAVQAA PGKSHSAAAL
LGRMDAARAQ LGSALTRIYP ADQAGYMQAL VLGNQDETDP ELYRRFARLG LTHIMAVSGM
HVAVMLGLLG FSLRQLRLTK ERILLLLMFA VPPYVLFTGA SPSILRAGLM ALLGLAAARA
GKLKDGLHLL AASAVLLLLW NPRLIESVSF QLSYIVTAGL ILGVPAVNRL LSRPRSRLRF
VQDAVVVTFV AQAISFPVTI YYFNQIHLLS LPANLLLVPF ISFLIMPAGA AVMLVEPIWP
GAAQLLANWS TEANMWTFRL IEWMGEWSDG STIWATPSLW WIVSYYAVLF GLLQSLGRWR
SCKQAAAEET CFSDNEDTQP LLPVKDTSRY SPSTAPAMSV QTRIRNVASS LRSPLTRSVL
TGSILLLLLL HAFHSGWYDR AAYVQFLNVG QGDAILIRTP SGQTILIDGG GTMQFRREAW
RQRRDPYEIG RKMLVPLLMK RGVSEIDLLV VTHLDQDHIG GLEAVLDGIP VKRLLWNGSL
KEAGETPPLL QRAINKGIPL YGAEAGMSWQ PDVSTRLDVL WPTKHNDMQP IEEQNEQSVV
LLLTLFNRSF LLAGDLGSVS ESAVMETAKS LALPARNTPI DVLKAGHHGS KNSTSAAWLS
YWKPSVSVLS AGIDNRYGHP SEDVLMRLKQ FSSRAVRTDL NGEIEFRVTP QGMDMRLLRG
N
//