ID A0A1H1ZNC6_9ACTN Unreviewed; 480 AA.
AC A0A1H1ZNC6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Serine protease, subtilisin family {ECO:0000313|EMBL:SDT35204.1};
GN ORFNames=SAMN04488543_3893 {ECO:0000313|EMBL:SDT35204.1};
OS Friedmanniella luteola.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Friedmanniella.
OX NCBI_TaxID=546871 {ECO:0000313|EMBL:SDT35204.1, ECO:0000313|Proteomes:UP000199092};
RN [1] {ECO:0000313|EMBL:SDT35204.1, ECO:0000313|Proteomes:UP000199092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21741 {ECO:0000313|EMBL:SDT35204.1,
RC ECO:0000313|Proteomes:UP000199092};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT629749; SDT35204.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H1ZNC6; -.
DR STRING; 546871.SAMN04488543_3893; -.
DR OrthoDB; 5165638at2; -.
DR Proteomes; UP000199092; Chromosome i.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000199092};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..480
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009267907"
FT DOMAIN 383..480
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT ACT_SITE 141
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 174
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 327
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 480 AA; 49264 MW; 59F90FC8801C9926 CRC64;
MNRLTGALAA AALVSSVSAG LTLPAHAAPE SGPTARYIVR TDAVGGADDA AQDVRRLGGD
VEHVYSEVFP GLAATLTADQ ARRLRASDEV AEVVPDRLFH ATGVQTNAPW ALDRLDQRPV
AGNKTYRYDT TGEGAFAFVL DTGLRFGHQQ FGGRAVSGYD FVDLDDDASD CDGHGTHVAG
SIGGAGYGVA KGVTLVGVRV LDCEGAGYAS DIIWALDWVA EVAADVPAVV NLSLGGPALD
ELDEAVERTV RAGIPVVVAA GNENGDACDV SPARVPAAIT VAAVDSADRR ARFSNRGRCV
DLFAPGVAVR SASNLSNTAT EVMSGTSMAA PHVTGAVARY LGAHPTATPA QAVGALTRTA
GADAVRDRAG SPDRLLYTGP VTAPGKPTKV AAKKNDRART ATVSWSTPVA DGGRAVTGYR
VTRNGKDARG QGPVTVTVSA GTRSHTFPRL RKGSAYTFTV RAVNAVGAGA PMSTSVPKLR
//
