ID A0A1H2DC04_9ACTN Unreviewed; 714 AA.
AC A0A1H2DC04;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:SDT80022.1};
GN ORFNames=SAMN04489716_9028 {ECO:0000313|EMBL:SDT80022.1};
OS Actinoplanes derwentensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=113562 {ECO:0000313|EMBL:SDT80022.1, ECO:0000313|Proteomes:UP000198688};
RN [1] {ECO:0000313|EMBL:SDT80022.1, ECO:0000313|Proteomes:UP000198688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43941 {ECO:0000313|EMBL:SDT80022.1,
RC ECO:0000313|Proteomes:UP000198688};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; LT629758; SDT80022.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2DC04; -.
DR STRING; 113562.SAMN04489716_9028; -.
DR OrthoDB; 3216872at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000198688; Chromosome i.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000198688}.
FT DOMAIN 316..494
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 497..597
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 714 AA; 76537 MW; 12DDC4C95AFFDE0D CRC64;
MSETIRYDRA DDGIVVLTLD DPSRGANTMN DAYVRSMEET VSRLEAERDE ITGVIITSAK
KSWFAGGDLD QLGSVPADRG GDVFAMSTRV KGQLRRLETL GRPVVAALNG SALGGGLELA
LATHRRIALS DPRLEIGLPE VTLGLLPAGG GVVRTVRLLG LATALTEVLL KGTRHKLAKA
VQLGLIDEVV DTPEQLITAA REWIIQNPGA VQPWDTKGYR IPGGSPSTPS LAAMLPAFPA
NLRKQLKNAP YPAPRNILSA AVEGAQVDVD TALVIETRYF VELVTGQVAK NMIKAFFFDL
NEVSQRDIGE VPPITKVAVL GAGMMGAAIA YVSARAGLPT VLRDVTLEGA QRGKAYSEKL
VGKDVSRGRI TPEKGEALLG LITATDQIAD LAGADLVIEA VFEDPALKHK VFAEIETVVA
PHALLCSNTS TLPITALADG VSRQADFIGL HFFSPVDKMP LVEVIKGEKT SDLTVRRSLD
VVRRLRKTPI VVNDSRGFFT SRVIGTFTNE GIALLAEGVA PASIEQASSQ AGYPAPVLQL
MDELTLTLPR KIRDEYRAAA SAAGRERETH PADEVIDRMI DEFGRPGRSG GAGFYEYTDG
KRTGLWPGLS AFARPDVAIP FEDLKERMLF IEAIETVKCL DEGVLTSVAE ANIGSILGIG
YPGWTGGVLQ YINQYDGGLP GFAARARQLA DRYGDRFTPP PLLLAKAEAN ETFV
//
