ID A0A1H2ENW9_9PSED Unreviewed; 358 AA.
AC A0A1H2ENW9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Small-conductance mechanosensitive channel {ECO:0000256|RuleBase:RU369025};
GN ORFNames=SAMN05216296_0957 {ECO:0000313|EMBL:SDT96862.1};
OS Pseudomonas pohangensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=364197 {ECO:0000313|EMBL:SDT96862.1, ECO:0000313|Proteomes:UP000243232};
RN [1] {ECO:0000313|Proteomes:UP000243232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17875 {ECO:0000313|Proteomes:UP000243232};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mechanosensitive channel that participates in the regulation
CC of osmotic pressure changes within the cell, opening in response to
CC stretch forces in the membrane lipid bilayer, without the need for
CC other proteins. Contributes to normal resistance to hypoosmotic shock.
CC Forms an ion channel of 1.0 nanosiemens conductance with a slight
CC preference for anions. {ECO:0000256|RuleBase:RU369025}.
CC -!- SUBUNIT: Homoheptamer. {ECO:0000256|RuleBase:RU369025}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU369025}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369025}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|RuleBase:RU369025}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369025}.
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DR EMBL; LT629785; SDT96862.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2ENW9; -.
DR STRING; 364197.SAMN05216296_0957; -.
DR OrthoDB; 9780668at2; -.
DR Proteomes; UP000243232; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR045275; MscS_archaea/bacteria_type.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR PANTHER; PTHR30221:SF18; SLL0590 PROTEIN; 1.
DR PANTHER; PTHR30221; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU369025};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU369025};
KW Ion transport {ECO:0000256|RuleBase:RU369025};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369025};
KW Reference proteome {ECO:0000313|Proteomes:UP000243232};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369025};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369025}; Transport {ECO:0000256|RuleBase:RU369025}.
FT TRANSMEM 14..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369025"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369025"
FT TRANSMEM 83..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369025"
FT DOMAIN 97..160
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT COILED 297..353
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 358 AA; 38987 MW; 7EC935DAA69CCEDA CRC64;
MLDMGKLQPF VLDMLPFLGV CLGVFLLLGL SHWLLLARHP DMGNEKRFPR QLILLGATLA
GLLLILLVMP IDQGTRGQVI GLLGLLISGL LAFSSTNVLG NLMSGLLLRM TKPFRLGDFI
RVGEHFGRVS ERGLFDTEIQ TENRELVALP NTYLISNPVT TIRSSGTIVS TELSLGFDVH
HAQIEPLLLQ AASASGLQDA FVHVLEIGNF AVTYRIAGFL EDPKHLLTAR SDLCRQVLDA
LHGQDIEILS PTYMVQRPLE ATARVIPPPV CAATADKTAA ETTEAPEELL FDKAEQAEKL
SAERKALRAS IEEMQANLKA AAADARAQIK AGIEEAQAQL QALEQARPDE EEQSAGLY
//
