ID A0A1H2EQ95_9FLAO Unreviewed; 567 AA.
AC A0A1H2EQ95;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Signal peptidase I {ECO:0000256|RuleBase:RU362042};
DE EC=3.4.21.89 {ECO:0000256|RuleBase:RU362042};
GN ORFNames=SAMN04487762_1011 {ECO:0000313|EMBL:SDT97261.1};
OS Polaribacter sp. Hel1_33_78.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1336804 {ECO:0000313|EMBL:SDT97261.1, ECO:0000313|Proteomes:UP000198843};
RN [1] {ECO:0000313|EMBL:SDT97261.1, ECO:0000313|Proteomes:UP000198843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hel1_33_78 {ECO:0000313|EMBL:SDT97261.1,
RC ECO:0000313|Proteomes:UP000198843};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|RuleBase:RU362042};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; Single-
CC pass type II membrane protein {ECO:0000256|RuleBase:RU362042}.
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362042}.
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DR EMBL; LT629794; SDT97261.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2EQ95; -.
DR STRING; 1336804.SAMN04487762_1011; -.
DR OrthoDB; 9802919at2; -.
DR Proteomes; UP000198843; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 2.
DR InterPro; IPR043739; DUF5684.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019533; Peptidase_S26.
DR NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF18936; DUF5684; 1.
DR Pfam; PF10502; Peptidase_S26; 2.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362042};
KW Membrane {ECO:0000256|RuleBase:RU362042};
KW Protease {ECO:0000256|RuleBase:RU362042};
KW Reference proteome {ECO:0000313|Proteomes:UP000198843};
KW Transmembrane {ECO:0000256|RuleBase:RU362042};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 86..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 125..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT TRANSMEM 541..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362042"
FT DOMAIN 124..284
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT DOMAIN 468..507
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 153
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 253
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 567 AA; 65476 MW; 48D2C1AFDCF2016D CRC64;
MTFTQWFIFF LVVQVIHFLG TWKLYVKAGR KAWEAAVPVY NGIVLMQIIN RPKWWVILLF
VPVVNLLMFP VIWIETIRTF GFYKKLESFL VIATLGLYIF YINYNTDAEY NAERSIKPRS
ELGEWVSSIA FAIIAATLVH TYFMQPFTIP TSSLEKSLLV GDYLFVSKFH YGARVPSTVI
AAPMVHDSLP FTGTASYLKK PQLPYTRLPG LQKIKNNDIV CFNWPADSLA TMWGDTSGKF
TYKPVDKKTN YVKRSVGIAG DSLEMRNGYF FINGKKNELP YRAKLQFYYT FECKQPISQS
TYPKFLLNKE KTGVYKILSE YWNNDKVQEA IKKNGNLSKI GEDSLYTEVA GGVNPQFAQR
LKMINVDHKI NINLTEEEVI RLEKYPLTVS VKKINHSPDN AIFPHVKKLG WSQDNFGPIY
IPKKGATVKL DSESIPFYKQ IIKNYESNDL VINGEDIFIN GEKTDSYTFK QDYFYLIGDN
RHNSLDARYW GYVPFDHVLG KPVMIWFSWD ANAPSFTAKL KSIRWNRMFT TVGGDGEPIS
YRYFVFALIA LYIGYSFYKG KKKTSKK
//