ID A0A1H2GMT6_9PSED Unreviewed; 859 AA.
AC A0A1H2GMT6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05216580_1874 {ECO:0000313|EMBL:SDU20986.1};
OS Pseudomonas guangdongensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1245526 {ECO:0000313|EMBL:SDU20986.1, ECO:0000313|Proteomes:UP000243063};
RN [1] {ECO:0000313|Proteomes:UP000243063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC 2012022 {ECO:0000313|Proteomes:UP000243063};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; LT629780; SDU20986.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2GMT6; -.
DR STRING; 1245526.SAMN05216580_1874; -.
DR Proteomes; UP000243063; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000243063}.
FT DOMAIN 689..705
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 615..622
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 859 AA; 95300 MW; 9427459864B56B20 CRC64;
MSQHDFSAHT PMMQQYLKIK QQHPDQLLFY RMGDFYELFY ADAQKAAKLL DITLTARGQS
AGQPIPMAGI PFHSAEGYLA KLVRLGESVA ICEQIGDPAT SKGPVERQVV RILTPGTVSD
EALLDERRDN LLAALLGDER LFGLAVLDIT SGRFSVQEIK GWESLLAELE RLNPAELLIP
DDWPQDLPAE RRPGARRRAP WDFDRATGFK ALCQQFATQD LNGFGCQNLT LAIGAAGCLL
LYARETQRGA LPHIRSLRHE SLDDAVILDA ASRRNLELDT NLAGGRDNTL QSVVDRCMTA
MGSRLLCRWL NRPLRERGII EGRQQAIGCL LDDYRFEPLQ PRLKEIGDVE RILARIGLRS
ARPRDLARLR DALAALPELQ HHLATLEAPR LQELAGSIRT YPELADLLAR AIIDTPPAVI
RDGGVIKRGY DAELDELQLL SENAGQYLMD LETREKTRTG LPNLKVGYNR IHGYYIELPR
VQAAQAPADY IRRQTLKGAE RFITPELKAF EDKALSAKSR ALAREKLLYE QLIEQLIEHL
APLQDTAAAL AELDVLGNLA ERALNLDFNC PRFVDQPCLR IEQGRHPVVE QVLSTPFVAN
DVSLDDSTRM LIITGPNMGG KSTYMRQTAL IVLLAHIGSY VPARACELSA VDRIFTRIGS
SDDLAGGRST FMVEMSETAS ILHNASERSL VLMDEVGRGT STFDGLSLAW AAAEHLARLR
AFTLFATHYF ELTVLPDSEP VVANVHLNAA EHHERIVFLH HVLPGPASQS YGLAVAQLAG
VPDAVIQRAR EHLRRLEETS LPHDGSAAPA RPGQAPAPLQ ADLFASQPHP LLEQIERIDP
DALTPRQALD LIYAWKMQI
//
