ID A0A1H2ICD6_9PSED Unreviewed; 327 AA.
AC A0A1H2ICD6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=thymidine phosphorylase {ECO:0000256|ARBA:ARBA00011892};
DE EC=2.4.2.4 {ECO:0000256|ARBA:ARBA00011892};
GN ORFNames=SAMN05216580_2896 {ECO:0000313|EMBL:SDU41789.1};
OS Pseudomonas guangdongensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1245526 {ECO:0000313|EMBL:SDU41789.1, ECO:0000313|Proteomes:UP000243063};
RN [1] {ECO:0000313|Proteomes:UP000243063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC 2012022 {ECO:0000313|Proteomes:UP000243063};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000749};
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DR EMBL; LT629780; SDU41789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2ICD6; -.
DR STRING; 1245526.SAMN05216580_2896; -.
DR OrthoDB; 9768896at2; -.
DR Proteomes; UP000243063; Chromosome i.
DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR Gene3D; 3.40.1030.10; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR InterPro; IPR035902; Nuc_phospho_transferase.
DR InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR10515:SF0; THYMIDINE PHOSPHORYLASE; 1.
DR Pfam; PF02885; Glycos_trans_3N; 1.
DR Pfam; PF00591; Glycos_transf_3; 1.
DR SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR SUPFAM; SSF47648; Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:SDU41789.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000243063};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDU41789.1}.
FT DOMAIN 22..79
FT /note="Glycosyl transferase family 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02885"
FT DOMAIN 107..246
FT /note="Glycosyl transferase family 3"
FT /evidence="ECO:0000259|Pfam:PF00591"
SQ SEQUENCE 327 AA; 35345 MW; 08821DBE7D8F3767 CRC64;
MTPIPTTPEE HPFAAFVRIL GKGKRGARDL TRDEAREAMG MLLDGRVEDV QLGAFLMLLR
HKEESAEELA GFTEAVRARV AAPAIAVDLD WPSYAGKKRH LPWYLLAAKA LAAGGVRIFM
HGGGAHTAGR LYSEQMLAAL EIPCCADWAE VEAALARGGL AFMPLGAWMP ALQRMIDLRN
TLGLRSPIHS LARVLNPLGA RCALQSIFHP GYQAVHREAS RLLGDHALVI KGDGGEIEAN
PDAAMHLYGA TGGQAWDEEW PALSAQRHVK PARLDPAHLL AVWRGEAQDA YGLLAVRASM
ALALRGLGLD REDAFARADA LWSARLG
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