ID A0A1H2IJ36_9ACTN Unreviewed; 414 AA.
AC A0A1H2IJ36;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Mycofactocin radical SAM maturase {ECO:0000313|EMBL:SDU44177.1};
GN ORFNames=SAMN04488563_1768 {ECO:0000313|EMBL:SDU44177.1};
OS Jiangella alkaliphila.
OC Bacteria; Actinomycetota; Actinomycetes; Jiangellales; Jiangellaceae;
OC Jiangella.
OX NCBI_TaxID=419479 {ECO:0000313|EMBL:SDU44177.1, ECO:0000313|Proteomes:UP000182977};
RN [1] {ECO:0000313|Proteomes:UP000182977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45079 {ECO:0000313|Proteomes:UP000182977};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT629791; SDU44177.1; -; Genomic_DNA.
DR RefSeq; WP_046771838.1; NZ_LT629791.1.
DR AlphaFoldDB; A0A1H2IJ36; -.
DR STRING; 419479.SAMN04488563_1768; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000182977; Chromosome i.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR023913; MftC.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR03962; mycofact_rSAM; 1.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR SFLD; SFLDF00316; C-terminal_tyrosine_decarboxyl; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 17..227
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 353..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 44917 MW; 0DB9C96C65DF9127 CRC64;
MTTATTPKLV ELFEHGLDAP ICLTWELTYA CNLSCVHCLS SSGRRDPREL STEECKAVID
ELERMQVFYV NIGGGEPTVR PDFWELVDYA TEHRVGVKFS TNGVKIDTEV AARLAASDYV
DVQISLDGAT ADVNDLVRGP GSYATAIRAM EHLAAAGFTG FKISVVVTRQ NAGQLDDFKA
IADRYGAQLR LTRLRPSGRG ADVWDELHPT AQQQRELYDW LLDHGENVLT GDSFFHLSAY
GESLPGLNLC GAGRVVCLID PVGDVYACPF AIHESFLAGN VRAEGGFTRV WRESDLFAEL
RSPQTGGACT KCQHFDSCRG GCMAAKFFTG LPLDGPDPEC VQGYGADALL ARGDVRPPKP
DVDHSHRTAP ASPRRGHGPV PVTIARRRPE RPPVSACEES PLAGLDLSGV RSNT
//
