ID A0A1H2JFL6_9ACTN Unreviewed; 1083 AA.
AC A0A1H2JFL6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN04488563_2646 {ECO:0000313|EMBL:SDU55199.1};
OS Jiangella alkaliphila.
OC Bacteria; Actinomycetota; Actinomycetes; Jiangellales; Jiangellaceae;
OC Jiangella.
OX NCBI_TaxID=419479 {ECO:0000313|EMBL:SDU55199.1, ECO:0000313|Proteomes:UP000182977};
RN [1] {ECO:0000313|Proteomes:UP000182977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45079 {ECO:0000313|Proteomes:UP000182977};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; LT629791; SDU55199.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2JFL6; -.
DR STRING; 419479.SAMN04488563_2646; -.
DR Proteomes; UP000182977; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 22..358
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 359..669
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1083 AA; 116525 MW; F79D56FF437EC07F CRC64;
MTQVIGGASI APAELARRLG QPDPTPEQAA AIAAPLAPGV VVAGAGSGKT ETMAARVVWL
VASGLVRPED VLGLTFTRKA ARELAARIRR RLAQLAARGL VPPDVLDGEP TVLTYDAYAG
RIVAEHALRL GREPGARLVT EAVTWQYSQR VVSSYDGDMD AVGYAPSTVV QKVLDLHNEL
AGHLVTPAQV QQYARELRAG VEALPKATGQ RTKDLLYADV AKGLAVQDAR VALLPVVEEF
RARKQTDEVL DFADQAELAA TLAARFPEVG VAERAAYGVV LLDEYQDTSH AQLVLLRSLF
GGGHPVTAVG DPCQSIYGWR GASAGTLTSF RREFQASDDG DGDTLARLDS LTTSFRNGAE
ILQVANRLSQ PLRAQGLDVP ELTAFPGLPP STVVASLHLT ADDEAADVAR RARAFWDASD
DGRTVAVLVR NRSLIPRLES ALRAADLPVE VVGVGGLLAT AEVGDVVATL RVVNDPSRGD
ALMRLLTGSR WRIGPRDLDA LARWARRLGR PDDDSGGARR PPTMREAAAE GITLDEVDEL
SIVDALDALP KGGDWFSAEG DRRLRALSAE LRELRSRTGQ SLTELVHDVQ RTLGLDVELA
ARRGPGGRAN LDRFLDVAAE FENNGHAGNL SGFLAYLDAA ETAERGLAPG EVEVSGDRVQ
VLTVHGAKGL EWDAVFVTGL VDKVFPSGGE KQRAWLGDPG ELPYALRGDA GSLPPLDLAG
VADQVGVRDA VDAFYGDAAA AARLEERRLA YVAVTRARRL LVCSGFCWDD GVRPRELSMF
LHEIKVACED GAGEIGVWVR APEDDDTNPL AQQVRELRWP YDPLGQRRSL LEDGAALVRA
AQGSVDGVLF DLAQPVTEWD AEVERLLAER ERHSSLRPID VALPEHLSVS QLVALRESPE
SLARALRRPV PRPPAPLARR GTLFHAWLES RWGALRLVDV DELPGYADDG AAPDRELASL
QEAFLRSAWA ARTPVEVEAP FELLVAGVLL RGRVDAVFTT DDGGIDVVDW KTGRPPANDE
EAATRTVQLA AYRLAFARLY DLPLDHVGAA FHHVRHDVTV RPADLMDEAR LTALVAAVPA
ADE
//