ID A0A1H2K047_9ACTN Unreviewed; 711 AA.
AC A0A1H2K047;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SDU62064.1};
GN ORFNames=SAMN04488563_3275 {ECO:0000313|EMBL:SDU62064.1};
OS Jiangella alkaliphila.
OC Bacteria; Actinomycetota; Actinomycetes; Jiangellales; Jiangellaceae;
OC Jiangella.
OX NCBI_TaxID=419479 {ECO:0000313|EMBL:SDU62064.1, ECO:0000313|Proteomes:UP000182977};
RN [1] {ECO:0000313|Proteomes:UP000182977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45079 {ECO:0000313|Proteomes:UP000182977};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; LT629791; SDU62064.1; -; Genomic_DNA.
DR RefSeq; WP_046768015.1; NZ_LT629791.1.
DR AlphaFoldDB; A0A1H2K047; -.
DR STRING; 419479.SAMN04488563_3275; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000182977; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..335
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 545..673
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 690..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 74353 MW; 4D2AAAE8BAA12F08 CRC64;
MASTRRRLGP LVCGRRSKWI VLGFWLVVMG VGFPLSAELT GAQDNDTASW LPGSAESTQV
FEAQQDAFQT GEELPAIVVY ERQGGITPED QAKAAADAEA FAGVEHVTGD VVGPIPSEDG
EALQVIVRVD PGDGGWFALG DAVDAMNDIL ADEPEGLSAY VAGPAGVSAD FADAFEGIDG
TLLYAAMGVV IVILLISYRS PVLWFIPVFS AFTALTAAQA VVYLLAEYAG VTVNGQTAGI
LLVLVFGAST DYALLLIARY REELRRHEDR HEAMAFALHR AGPAIVASAA TVTVGMLCLL
AAEMNSTRGM GPVLAVGIVI GLAAMLTLLP ALLVISGRWV FWPLKPRFGS DEPTERGFWA
RTGRAIAHRP RTVWIGTSLA LGAMALGLLG LNTGVIANAD AFVDRPASIA GEEALARHFP
AGTGSPVTVI SNAGAADDVR QAFEDTDGIA EVTEPESIGD LVYMEGTLDA APDSPAAQDT
VEAVRDSVHA VPDADALVGG NTAIALDAKN AAARDSTVIM PLVLVAVFVI LMILLRAFVA
PLILVATVVL SFAAALGLSS LIFEHLLGFA GADTAFPLFV FVFLVALGID YNIFLMTRVH
EEAKQHGTRR GALIGLAATG GVITSAGLVL AGTFAVLATL PVVAFAEIGI AVALGVLLDT
LIVRSILVTA LNLDLGRVMW WPSALSKHAE PTAAEVADEP DEVTEEPRPV R
//
