ID A0A1H2M2M1_9ACTN Unreviewed; 734 AA.
AC A0A1H2M2M1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=SAMN04488544_1301 {ECO:0000313|EMBL:SDU87513.1};
OS Microlunatus sagamiharensis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=546874 {ECO:0000313|EMBL:SDU87513.1, ECO:0000313|Proteomes:UP000198825};
RN [1] {ECO:0000313|Proteomes:UP000198825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21743 {ECO:0000313|Proteomes:UP000198825};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; LT629799; SDU87513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2M2M1; -.
DR STRING; 546874.SAMN04488544_1301; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000198825; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645,
KW ECO:0000313|EMBL:SDU87513.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000198825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..266
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 369..641
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 688..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 77300 MW; B56221CA535CADFA CRC64;
MTPPTLTPAR RPRHVLRAGG LFVLVSVVCG LLVTAAALPL VGGAAWGAKE AREGMASLPL
EFDAPAQSQR TRVLDADGKV IAYFYDQNRD YVTLDDIAPV MRTALISIED HRFYEHGPLD
AQGTLRAFVT NLFAGGVTQG GSTLTQQYVK QVQVNAAALK GDESGVEAAT DSSYQRKLRE
LRYAVSVEDT MSKDQILERY LNIAYFGGGA YGIEAASEHY FGTSAAKLTL PQAAMLAGLV
QNPNGYDPVA HPDAGIQRRN VVLDRMAELG TASQAAVTKA KKSKFDAKAG DDVASGCQST
DYPFICDYVK RTVLTMPSLG KTEKAREQAL MRGGLTIRTA IDPSTQDAVQ KAVSGAVGAK
DPVIAAMDMI EPGTGRIIAM AQSRPVMGAS AKKGQTYWNY SVSPEMGGAQ GFQAGSTFKA
FTAAAALEQG VPLSQRYDAK ARMDFSGARF DSCEGNVPIV GEFPVSNSTG VNGSMDMYRA
ADFSVNTYFV QLALDVGMCD VTKMAEKLGV ESNTPGQPIS SYDSLPSFTL GTAETNPLSV
ANAYATFASG GIHCDPVIVT KVTDSSGKSL EVPDAGCKRV ISEDVASAMD SLLSSVVTRG
TGARARTADG RPQAGKTGTI DSNAAVWYAG YTPQVAGAAM ISIDKERKTP TSLKGYTVPS
TSLYLEGSGS GDAGRRIWKP AMEQYLQGKP AEAFPSPPAD LVRGPSPFGR GQGTGQDGRD
GEYGAGQQPG PGGR
//
