ID   A0A1H2MFN3_9ACTN        Unreviewed;       774 AA.
AC   A0A1H2MFN3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN   ORFNames=SAMN04488544_1965 {ECO:0000313|EMBL:SDU91904.1};
OS   Microlunatus sagamiharensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Microlunatus.
OX   NCBI_TaxID=546874 {ECO:0000313|EMBL:SDU91904.1, ECO:0000313|Proteomes:UP000198825};
RN   [1] {ECO:0000313|Proteomes:UP000198825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21743 {ECO:0000313|Proteomes:UP000198825};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000256|ARBA:ARBA00038000}.
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DR   EMBL; LT629799; SDU91904.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2MFN3; -.
DR   STRING; 546874.SAMN04488544_1965; -.
DR   Proteomes; UP000198825; Chromosome i.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR   Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR   PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198825};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          409..761
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   REGION          462..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..492
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  82194 MW;  FE827C54983D45CE CRC64;
     MAPYARRLIQ QAGVPRVASV TGLPPAVALQ QQRGGVGSRS SVGTLTTLSN TLRMLFSRVG
     DYPDGAERLD SDAFSANTPA GACPHCHGVG QVYAVSESSV VPDPSLSIRD GAVAAWPGAW
     LGKNFRDILR VLGYDVDRPW RELDRADRDW ILFTDEHPVV TVNFEREAGR IQRPYQGRWT
     GVREYVLTTF ATTRSAPIRR RLRGYLDASP CPVCGGRRLR PEALAVTFAG HDIASLTALP
     VERLTAVLEE AVGAHDPDSA AGTLLGELLG RTALVVDLGL GYLALDRALP TLSSGELQRL
     RLATQLRSGL FGVVYVLDEP SAGLHPADTE ALQEVLLGLR DAGNTVLLVE HDLDLVRQAD
     WLVDVGPGAG SGGGLVLHSG PVDGLAAVEA SATRPYLDPA YRPVVNASPR APQEWLRLEG
     VSAHNLHDLD VALPLGTLTV VTGVSGAGKT SLVRVLTGAV RDHLGLPDEP EEDGEEPDED
     TEDTTAGEAD DTAADDVEPR PEVRRAYGLE QVTRLVVVDQ RPIGRTPRSN LATYTGLFDA
     VRSAYARTPE AKARRWSASR FSFNVAAGRC PTCKGEGFVA VRMLFLPGSY SRCPTCHGSR
     YAAETLEVTR GGLSIADVLD LDVDQAVEAL ADIPAAVRGL TALRDVGLGY LRLGQPATEL
     SGGEAQRIKL ATELQRSRLA GTLYVLDEPT TGLHPADTER LLRLLQGLVD GGSTVVVVEH
     DAAVALAADW LVDLGPGGGD AGGRVVDAGT PVEVARRALG PTGSHLARRL SPTG
//