ID   A0A1H2MH94_9PSED        Unreviewed;       392 AA.
AC   A0A1H2MH94;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Heme d1 biosynthesis radical SAM protein NirJ {ECO:0000313|EMBL:SDU92454.1};
GN   ORFNames=SAMN05216202_1703 {ECO:0000313|EMBL:SDU92454.1};
OS   Pseudomonas mucidolens.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=46679 {ECO:0000313|EMBL:SDU92454.1, ECO:0000313|Proteomes:UP000198600};
RN   [1] {ECO:0000313|Proteomes:UP000198600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 2223 {ECO:0000313|Proteomes:UP000198600};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; LT629802; SDU92454.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2MH94; -.
DR   STRING; 46679.SAMN05216202_1703; -.
DR   OrthoDB; 9792276at2; -.
DR   Proteomes; UP000198600; Chromosome i.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR023992; HemeD1_Synth_NirJ.
DR   InterPro; IPR017200; PqqE-like.
DR   InterPro; IPR007197; rSAM.
DR   NCBIfam; TIGR04051; rSAM_NirJ; 1.
DR   PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR   PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR   Pfam; PF13353; Fer4_12; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR   SFLD; SFLDG01383; cyclic_pyranopterin_phosphate; 1.
DR   SFLD; SFLDF00393; heme_D1_biosynthesis_(NirJ-lik; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          22..236
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   392 AA;  44071 MW;  9984CF76B17AEF4A CRC64;
     MLRISHYLRT LAGHCPPPRS ATPGSDRAPV VIWNLLRRCN LTCKHCYATS ADSVFRDELD
     TSAALRVIDD LHAAGVKVLI LSGGEPLLRA DLFELSAYAR SKGFFVALSS NGTLIDESNI
     QQITDACFDY VGISIDGLQP THDAFRQSQG SFQRSMHAIS LCREADIRVG LRTTLTQENH
     AQLPQLLGLM REYDVQKFYL SHLNYSGRGK RSRQLDAHRQ MSRDALERIF EQAWKDIQHG
     ISSDFVSGNN DADAVLLLQW VQRHLPQHYP HLEHLLRAWG GNASGSGIAN IDNTGEVHPD
     TYWWQHSVGN VRRTAFRSLW LERPDPLLLR LREHPRVVGG RCAECRWLGI CNGNTRTRAW
     ADGDLWGEDP GCHLSDTEIA RTPPTLIPCS AR
//