ID A0A1H2MN89_9ACTN Unreviewed; 507 AA.
AC A0A1H2MN89;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04488544_2382 {ECO:0000313|EMBL:SDU94562.1};
OS Microlunatus sagamiharensis.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=546874 {ECO:0000313|EMBL:SDU94562.1, ECO:0000313|Proteomes:UP000198825};
RN [1] {ECO:0000313|Proteomes:UP000198825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21743 {ECO:0000313|Proteomes:UP000198825};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LT629799; SDU94562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2MN89; -.
DR STRING; 546874.SAMN04488544_2382; -.
DR OrthoDB; 9786919at2; -.
DR Proteomes; UP000198825; Chromosome i.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDU94562.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198825};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 33..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..256
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 264..472
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 486..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 53082 MW; B2A365DB626AC308 CRC64;
MAADQRRAQG PGEVVGTVRM LTFLWDHPMQ RRVSLLTTVA VALAVVVCSA VGYLALCSTL
VSTSQEIALG IAQDLAGPAA RAIEGTGTLP ADLQQPGQVV VQAVDASGTV LRTPGDDLAL
VVEPSDLEAA GPAGGLVQRT GRTVDGQRYA VVALPLPGTG HALLVGRPLG PALHVLEVQR
FILGAVCLAG VLAAAVVGVL VGASGLRPMR QLTEAMEHVT ATQDYQPVSV RYAKGDLVTM
AGSFNLMLAS LTKARERQSR LVADAGHELR TPLTSLRTNV DLLAEDLGRD RLSEEQKAAV
LGDVQGQLGE LTEMIGDLVH VARDDSTLTL APLDVVELVR DAVERVQRRA AGITFDVALQ
PLFVVADPDS LRRAVTNLLD NAVKWSPPGA TVRVRLEGNR LRVSDAGPGI PEADLPYVFD
RFFRGESGRH TKGTGLGLAI VAKTMDEIGG SVHAGRSAEG GAELTLQLPG VTSREAVSSL
LVPAREAAPE TAPVTATAKK GRLTPAR
//