ID A0A1H2PTN9_9BURK Unreviewed; 1201 AA.
AC A0A1H2PTN9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN05216551_11224 {ECO:0000313|EMBL:SDV50488.1};
OS Chitinasiproducens palmae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Chitinasiproducens.
OX NCBI_TaxID=1770053 {ECO:0000313|EMBL:SDV50488.1, ECO:0000313|Proteomes:UP000243719};
RN [1] {ECO:0000313|Proteomes:UP000243719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS23 {ECO:0000313|Proteomes:UP000243719};
RA Varghese N., Submissions S.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FNLO01000012; SDV50488.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2PTN9; -.
DR STRING; 1770053.SAMN05216551_11224; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000243719; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000243719}.
FT DOMAIN 665..826
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 847..1001
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 357..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 132282 MW; 9FDF0158890A2E56 CRC64;
MSDKKPSSSA TVSLVKEGHR HVVDGIAGSA DALVIARYLQ SHRAQLAMLA VVCANASDAQ
RLLAEIAYFA PQARVRVLPD WETLPYDTFS PHQDLVSERL ATLHDLSAGR CDVLLVPAST
ALYRMPPAAF MAAYTFEFAQ NQKLDEAKLR AQLTLASYEH VNQVVRPGEY CVRGSLIDLF
PMGSALPYRI DLFDDQVDSI RAFDPDSQRS LYPVKDIRLL PGREFPFDEA ARTAFRKRWR
ETFEGDPSRA TIYRDAGNGV PSGGIEYYLP LFFDETATLF DYLPAGSQLV TVGDLDEAMS
RFMRDTEQRY GFLSHDSERP ILDPSRLFLS SEAFFARARG LARLVLRRDV PATDATNATD
AANATGGTDD SAASATAAGA AHADRPSGEA ASARAPRKHA PVALPLPSLS VDRRSDDPLA
ALRGFTHGAY RVLLAAESAG RRETIAQLLI DNRMPAAPVD DFASFLASDV AFGLGVAPLA
TGFVLPDARV AVVTETELYG ALARRTQRRR QEQTSSVDEM VRDLSELKIG DPIVHSQHGI
GRYLGLATMD LGEGDTEFLH LEYAGPSKLY VPVAHLHLIS RYSGADPDTA PLHALGSGQW
DKARRRAAKH IRDTAAELLN LYARRAARTG HAFELSPRDY ETFAESFGFE ETPDQAAAIN
AVINDMTSGQ PMDRLVCGDV GFGKTEVALR AAFIAVLGGK QVALLCPTTL LAEQHFQTFT
DRFSQWPVRI AELSRFKSGK ETTQAVKALA SGDVDIVIGT HKLLSQDVVF KRLGLVIIDE
EHRFGVRQKE TLKALRAEVD ILTLTATPIP RTLGMALEGL REFSVIATAP QKRLAIKTFV
RREDDSVIRE AMLRELKRGG QVYFLHNEVE TIENRRTMLE ALVPEARIVV AHGQMNEREL
ERVMRDFIGR RANVLLCTTI IETGIDVPNA NTILIHRSDR FGLAQLHQLR GRVGRSHHQA
YAYLLVRDPE TLTSQATRRL EAIQQMEELG AGFYLAMHDL EIRGAGEVLG DKQSGEIHEI
GFQLYTDMLA DAVDALRAGR EPDLTAPLAA TTEINLHVPA ILPADYCGDV QERLTLYKRL
ASCTTFDAVD AVHEELIDRF GKLPPQAVAL VETHRLRLMA KPLGVAKIDA SEVAVGIQFV
PDPPIDAMRI IEMVQKNRHV KLAGQDRLRL EIPTPDLPAR IALLKDTLRQ LGRAETAGAA
R
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