ID   A0A1H2Q763_9FIRM        Unreviewed;       339 AA.
AC   A0A1H2Q763;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase {ECO:0000313|EMBL:SDW02850.1};
GN   ORFNames=SAMN05660923_00073 {ECO:0000313|EMBL:SDW02850.1};
OS   Tepidimicrobium xylanilyticum.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Tepidimicrobiaceae;
OC   Tepidimicrobium.
OX   NCBI_TaxID=1123352 {ECO:0000313|EMBL:SDW02850.1, ECO:0000313|Proteomes:UP000198828};
RN   [1] {ECO:0000313|EMBL:SDW02850.1, ECO:0000313|Proteomes:UP000198828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23310 {ECO:0000313|EMBL:SDW02850.1,
RC   ECO:0000313|Proteomes:UP000198828};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; FNNG01000001; SDW02850.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2Q763; -.
DR   Proteomes; UP000198828; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR006360; Mtase_MtaA_CmuA.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   NCBIfam; TIGR01463; mtaA_cmuA; 1.
DR   PANTHER; PTHR47099; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR   PANTHER; PTHR47099:SF1; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR   Pfam; PF01208; URO-D; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   4: Predicted;
KW   Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW   Methyltransferase {ECO:0000313|EMBL:SDW02850.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198828};
KW   Transferase {ECO:0000313|EMBL:SDW02850.1}.
FT   DOMAIN          3..336
FT                   /note="Uroporphyrinogen decarboxylase (URO-D)"
FT                   /evidence="ECO:0000259|Pfam:PF01208"
SQ   SEQUENCE   339 AA;  37425 MW;  E8C9F1868F26515E CRC64;
     MNSRERLLSA LKGNKVDRLP CICPGGMMNM IITELMERTG IMWPDAHIDA NKMADLAAAV
     YEYGMFENYG VPFCMTIEAE AMGAGIDMGS KIFEPHVVDY VIDSVSEYNK LKALDVNSGR
     AKVTIDAISI LNNKGGGVPI VGNLSGPISV ASSLMEPVTY YKELRRKRED SHKFMEFVTE
     QIIKFGQAQV EAGADLITIS DPSGTGEILG PKYFEEYAVK YLNMLIDGIR EVDKDFPIIV
     HICGQMRSVY SQINELKADA FSFDAVVNIK EIRKHMEDKI LMGNISSFAL QSANEEKIKR
     MTENSINSGI NIVSPACGLG TQSPMKNIQA ILKTVRGEN
//