ID A0A1H2RN14_9FLAO Unreviewed; 801 AA.
AC A0A1H2RN14;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SDW20757.1};
GN ORFNames=SAMN04487892_0727 {ECO:0000313|EMBL:SDW20757.1};
OS Allomuricauda zhangzhouensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Allomuricauda.
OX NCBI_TaxID=1073328 {ECO:0000313|EMBL:SDW20757.1, ECO:0000313|Proteomes:UP000199592};
RN [1] {ECO:0000313|Proteomes:UP000199592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25030 {ECO:0000313|Proteomes:UP000199592};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; FNMY01000001; SDW20757.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2RN14; -.
DR STRING; 1073328.SAMN05216294_2079; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000199592; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..307
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 801 AA; 88519 MW; 842BBC7BDDDA009D CRC64;
MKRHINKVAV IGSGIMGSGI ACHFANIGVE VLLLDIVPRE LNEKEKANGL TLEDKVVRNR
LVNDSLTAAL KSKPSPIYHQ KFANRITTGN MEDDISKVAD VDWIIEVVVE RLDIKKQVFE
NLDKHRKPGT LITSNTSGIP IKFMSEGRSE DFQKHFCGTH FFNPARYLKL FEIIPGPKTS
QDILDFLNGY GEQFLGKTSV VAKDTPAFIG NRIGIFSIQS LFHAVKEMGM TVEEVDKLTG
PVIGRPKSAT FRTVDVVGLD TLVHVANGIS ENCKDDERHE LFQLPDFIST MMENKWLGSK
TGQGFYKKVK GDDGKSEILT LDLNTMDYRS KKSAKFATLE LTKTIDKVID RFPVLVNGKD
KAGEFYRKSF GALFAYVTHR IPEISDELYK IDDAMKAGFG WEHGPFQIWD AVGLEKGLEF
IKAEGLEAAS WVADMKAAGV DSFYTVKDGA TYFYDISKKA MEKVPGQDAF IILDNIRKSN
EVFKNSGVVI EDLGDGILNC EFQSKMNTIG GDVLAGLNKA IDLAEKDFQG LVVGNQAANF
SVGANIGMIF MMAVEQEYDE LNMAIKMFQD TMMRMRYSSI PTVSAPHGMT LGGGCELSLH
ADKIVAAAET YIGLVEFGVG VIPGGGGSKE MALRASDTFR KNDVELNVLQ EYFLTIGMAK
VSTSAYEAFD LGILQKGKDV VVVNKDRQIA TAKAHAKLMA EAGYTKPVKR KDVKVLGKQA
LGMFLVGTDS MEAGHYISEH DKKIADKLAY VMAGGDLSEA TMVTEQYLLD LEREAFLSLC
TERKTLERIQ HMLKTGKPLR N
//
