ID A0A1H2RSX5_9FIRM Unreviewed; 301 AA.
AC A0A1H2RSX5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Lipid kinase, YegS/Rv2252/BmrU family {ECO:0000313|EMBL:SDW22572.1};
GN ORFNames=SAMN05216391_103112 {ECO:0000313|EMBL:SDW22572.1};
OS Lachnospiraceae bacterium KHCPX20.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1855375 {ECO:0000313|EMBL:SDW22572.1, ECO:0000313|Proteomes:UP000199590};
RN [1] {ECO:0000313|EMBL:SDW22572.1, ECO:0000313|Proteomes:UP000199590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHCPX20 {ECO:0000313|EMBL:SDW22572.1,
RC ECO:0000313|Proteomes:UP000199590};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the diacylglycerol/lipid kinase family.
CC {ECO:0000256|ARBA:ARBA00005983}.
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DR EMBL; FNOC01000003; SDW22572.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2RSX5; -.
DR STRING; 1855375.SAMN05216391_103112; -.
DR Proteomes; UP000199590; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR005218; Diacylglycerol/lipid_kinase.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR NCBIfam; TIGR00147; YegS/Rv2252/BmrU family lipid kinase; 1.
DR PANTHER; PTHR12358:SF106; LIPID KINASE YEGS; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDW22572.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000199590};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..137
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 301 AA; 32873 MW; F7CD55909634ED04 CRC64;
MLGVFFMGMK LLFIYNPHSG KGMIKNHLSD IMDLLIKAGY TVTVYATQYQ GDAEDKARQE
AGNFDRIICS GGDGTLDEVV TGIMSSGHKV PVGYIPAGST NDFGNSLGID KDMLKAARVA
ATGHPLAIDI GKFGETNFVY VAAFGIFTEV SYQTSQQLKN TIGHTAYLLE AIKQLRDIKS
YRMQVEYDGN VLYDEFIYGM ITNTKSVGGI KGIIPGDISL SDGKFEVTLI KAPKNPIELN
EIVQTLAGPR EESELVYSFQ ADHLVLKATE NVPWTLDGEY GGAPSVVEIV NLHHAMEIMV
E
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