ID A0A1H2RUS1_9BACL Unreviewed; 696 AA.
AC A0A1H2RUS1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:SDW23045.1};
GN ORFNames=SAMN05444487_10217 {ECO:0000313|EMBL:SDW23045.1};
OS Marininema mesophilum.
OC Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
OC Marininema.
OX NCBI_TaxID=1048340 {ECO:0000313|EMBL:SDW23045.1, ECO:0000313|Proteomes:UP000198534};
RN [1] {ECO:0000313|EMBL:SDW23045.1, ECO:0000313|Proteomes:UP000198534}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45610 {ECO:0000313|EMBL:SDW23045.1,
RC ECO:0000313|Proteomes:UP000198534};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FNNQ01000002; SDW23045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2RUS1; -.
DR STRING; 1048340.SAMN05444487_10217; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000198534; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198534};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..161
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 170..333
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 373..682
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 323..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 77102 MW; 58B548D757B88734 CRC64;
MQELKERIST WLRQLGISQR NAFILLGVIF LVGGLGIYYA VRDTGPPPQV VMARYAKDWE
KGDYKSMYHL LSTDAKQKIS QETFIRRHKA IATGISQKKI AFTSAKTNEE EPETIPFTTT
IQSSIVPKVT FKNKAIMVED DEGWRVDWKP SLIFPSLKEG DRVRVTQTPP GKRGEITARN
GEPLAVNDEK TAIGIIPNQV HDLRKTSTKL AKALSIPFDQ VYNKVKDEKN PSAFITIQSF
KGKDQEKATK LAKSIPEITA RDASTRRYPQ GSLTAHLTGY IRPITKDELA KKKKDGYQEG
DWLGHSGLEE YQGNTLRGKP GYRIATTSSN GKEKSLIASR SGTDGQDIQT TIDLKTQKQM
LRVIQQKSSD KGGGVAIDPK NGDLLALVSS PSYDPNLFVD GMSKSAWATI NSSNQPIANR
AKIPYAPGST MKAITSSIGL DSKKITPKTT YNTESGKWQK SPSWGGYYVR RVDNPGGPIN
LAKGLAWSDN IYFARVGIKV GRETMIDYLQ KYGFGKNMDI PLDVTPSQIS NNGKLSGEIQ
LADTSYGQGQ LLISPLHLAT MYSTFANDGD LLKPRITMKK GKTNDIEYWQ KDVVSPEVAK
QVRELLKGVV TLPKGSGRTL RTPGVELGAK TGTAELKASM NDKDQRQLGW LAWMANREKD
KKPDIVCVAY VDEVQNRGGS HYLFPGVKKM LKGRYP
//
