ID A0A1H2S5M4_9FIRM Unreviewed; 451 AA.
AC A0A1H2S5M4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Putative efflux protein, MATE family {ECO:0000313|EMBL:SDW26878.1};
GN ORFNames=SAMN05216391_1048 {ECO:0000313|EMBL:SDW26878.1};
OS Lachnospiraceae bacterium KHCPX20.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1855375 {ECO:0000313|EMBL:SDW26878.1, ECO:0000313|Proteomes:UP000199590};
RN [1] {ECO:0000313|EMBL:SDW26878.1, ECO:0000313|Proteomes:UP000199590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHCPX20 {ECO:0000313|EMBL:SDW26878.1,
RC ECO:0000313|Proteomes:UP000199590};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNOC01000004; SDW26878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2S5M4; -.
DR STRING; 1855375.SAMN05216391_1048; -.
DR Proteomes; UP000199590; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd13138; MATE_yoeA_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43549; MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED; 1.
DR PANTHER; PTHR43549:SF2; MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199590};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 451 AA; 48791 MW; 0D42FA4A4B7432D3 CRC64;
MELDMTKGRP MPIIFRFFLP IFLGNMFQQV YNLVDSIIVG QFVGRNAFAA VGSTGTIMFL
IFGFANGLAT GFTVLTSQKF GAKDERGIRR SVANAMLLCV IVAVVTTVLS LTFMPTILHV
MNTPAGIYQD AYTYITIISS GIACCCFYNL FSSLLRSVGN SRVPLYFLIF SAGLNIALDL
LLIIGFQMRV AGAALATIVS QGVSAVLCAF YIFTKVPMLR PRKEDWGFHP ECTRRQMGVG
LPMALQFAIT ASGTMIMQSA INKFGEVAIA GFTASSKVGG LLTQAFPALG QSMATYSGQN
YGKGDVDRIH QGSHVAVVMA IVASIVGAVL ALLLLRPAIP LFMGKNVDMS AILPWAKQYT
YVSIIFYIPL GVLFIYRDMM QGCGYGFLPM VGGVLELVAR VVMSFLSIQF GSYLLGVSGD
PAAWFVTGVF SAIAYKVVMK DVEKKFSSGK M
//
