ID A0A1H2SN55_9FIRM Unreviewed; 1226 AA.
AC A0A1H2SN55;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05216391_10549 {ECO:0000313|EMBL:SDW32514.1};
OS Lachnospiraceae bacterium KHCPX20.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1855375 {ECO:0000313|EMBL:SDW32514.1, ECO:0000313|Proteomes:UP000199590};
RN [1] {ECO:0000313|EMBL:SDW32514.1, ECO:0000313|Proteomes:UP000199590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHCPX20 {ECO:0000313|EMBL:SDW32514.1,
RC ECO:0000313|Proteomes:UP000199590};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FNOC01000005; SDW32514.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2SN55; -.
DR STRING; 1855375.SAMN05216391_10549; -.
DR Proteomes; UP000199590; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE/NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:SDW32514.1};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199590}.
FT DOMAIN 2..473
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 501..794
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1226 AA; 140006 MW; 8AD203F570466697 CRC64;
MSKWTTAQQE VIDTRNASLL VSAAAGSGKT AVLVQRIIDL VKGVGSEPVD IDRILVVTFT
RAAAKEMKER VYKSLKEYCR EHPHDARMQR QKTLVHSAHI CTIDSFCQDV VRSHFHEIDV
DPQARIADTG ELTLLSEEVM QELLEEEYEK KDPDFLALID AFSRKERDDQ VMEIITQVER
AAMASPWPEQ YLDQLLVSYE VDTVSEVEEL PWMKQLVAGV RALAKDLGSH SRRLYAQLVN
EEIKGQPHPY LPALLDDQSY FDELSLATSY DSLYRIVSAH TKWTTFKRLS GASETDKELA
KSIQEQRNAY KKIVAGDIEK VITGSLDDIL DEMKRVAPFA RITVSLTKKY IEAFYKKKQE
KNVLSFSDLE HKALEVLVRK EDNRPTAQGL AYRNQFEEIM VDEYQDSNEL QELLLSSITR
DEKNYFMVGD VKQSIYRFRQ ACPDIFLEKC QRYKNKQGET FRRIDLDQNF RSRLEVIRPV
NDIFRMIMKE DLGGVEYDEV AELKLGATWV PKPVPERSCQ METIVIPSAD ESLQEALDGK
EKESLEAVVI ASKIRELMGT MQVYDKDTGS MRPITYNDIV ILHRSANAVS DSIIRILSAR
GIPARSISNK GYFSAVEVQT ALAALKIIDN PRQDIPMAAV LHSPMVGLSE ETLGRIAVAH
KDLGFAEAVL AEREENRAAI DEKEREKLSR FYERLSYYRS HVADTPIFEL LQQILTESGY
MTYVSGLTGG VRKRGNLEML LEKAIAYQHS SYQGIFHFLS YIDKLCTYDA DTGEADDTAG
EEAVRIMTIH KSKGLEFPVV FVAGCGKKFQ FDNAAVVLDR KFGMAMQYID AKRRVKTKTL
YQQAMESEMK IAQLGEELRV YYVALTRARD KLILVGEASK TKMESYEKEF FYPSNALSFV
ERKNATSFFD YAIPALKATG YPVTIPTADQ LVSEEVKAQI QELDKKSFLA DIGSLPASQR
VEKLLEYYHS RYPYEDAVRT KMKYSVSEIK QRVMQEQEQA MTENAQDLSR EFMDKEAVIE
ADIEAVPLDT PEETFTATVP LFLGGEKAEN QPALRGTAMH RFLEKLDFSM EDLANTYEAQ
LSYELSHGFL TEEQKGLLQV SKLRAFMKSD LARRMKIADQ KGKLYREQAF VMGDDPEVFL
SETEGNPELD IQDQVIVQGI MDAFFIEDDH IVLVDYKTDY VKTEQQLLKR YRKQMVLYKM
ALERSFGLPV TEIYLYSFAL GRSVLV
//