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Database: UniProt
Entry: A0A1H2SN55_9FIRM
LinkDB: A0A1H2SN55_9FIRM
Original site: A0A1H2SN55_9FIRM 
ID   A0A1H2SN55_9FIRM        Unreviewed;      1226 AA.
AC   A0A1H2SN55;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN05216391_10549 {ECO:0000313|EMBL:SDW32514.1};
OS   Lachnospiraceae bacterium KHCPX20.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1855375 {ECO:0000313|EMBL:SDW32514.1, ECO:0000313|Proteomes:UP000199590};
RN   [1] {ECO:0000313|EMBL:SDW32514.1, ECO:0000313|Proteomes:UP000199590}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KHCPX20 {ECO:0000313|EMBL:SDW32514.1,
RC   ECO:0000313|Proteomes:UP000199590};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FNOC01000005; SDW32514.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2SN55; -.
DR   STRING; 1855375.SAMN05216391_10549; -.
DR   Proteomes; UP000199590; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014152; AddA.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR02785; addA_Gpos; 1.
DR   PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE/NUCLEASE SUBUNIT A; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW   ECO:0000313|EMBL:SDW32514.1};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199590}.
FT   DOMAIN          2..473
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          501..794
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         23..30
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1226 AA;  140006 MW;  8AD203F570466697 CRC64;
     MSKWTTAQQE VIDTRNASLL VSAAAGSGKT AVLVQRIIDL VKGVGSEPVD IDRILVVTFT
     RAAAKEMKER VYKSLKEYCR EHPHDARMQR QKTLVHSAHI CTIDSFCQDV VRSHFHEIDV
     DPQARIADTG ELTLLSEEVM QELLEEEYEK KDPDFLALID AFSRKERDDQ VMEIITQVER
     AAMASPWPEQ YLDQLLVSYE VDTVSEVEEL PWMKQLVAGV RALAKDLGSH SRRLYAQLVN
     EEIKGQPHPY LPALLDDQSY FDELSLATSY DSLYRIVSAH TKWTTFKRLS GASETDKELA
     KSIQEQRNAY KKIVAGDIEK VITGSLDDIL DEMKRVAPFA RITVSLTKKY IEAFYKKKQE
     KNVLSFSDLE HKALEVLVRK EDNRPTAQGL AYRNQFEEIM VDEYQDSNEL QELLLSSITR
     DEKNYFMVGD VKQSIYRFRQ ACPDIFLEKC QRYKNKQGET FRRIDLDQNF RSRLEVIRPV
     NDIFRMIMKE DLGGVEYDEV AELKLGATWV PKPVPERSCQ METIVIPSAD ESLQEALDGK
     EKESLEAVVI ASKIRELMGT MQVYDKDTGS MRPITYNDIV ILHRSANAVS DSIIRILSAR
     GIPARSISNK GYFSAVEVQT ALAALKIIDN PRQDIPMAAV LHSPMVGLSE ETLGRIAVAH
     KDLGFAEAVL AEREENRAAI DEKEREKLSR FYERLSYYRS HVADTPIFEL LQQILTESGY
     MTYVSGLTGG VRKRGNLEML LEKAIAYQHS SYQGIFHFLS YIDKLCTYDA DTGEADDTAG
     EEAVRIMTIH KSKGLEFPVV FVAGCGKKFQ FDNAAVVLDR KFGMAMQYID AKRRVKTKTL
     YQQAMESEMK IAQLGEELRV YYVALTRARD KLILVGEASK TKMESYEKEF FYPSNALSFV
     ERKNATSFFD YAIPALKATG YPVTIPTADQ LVSEEVKAQI QELDKKSFLA DIGSLPASQR
     VEKLLEYYHS RYPYEDAVRT KMKYSVSEIK QRVMQEQEQA MTENAQDLSR EFMDKEAVIE
     ADIEAVPLDT PEETFTATVP LFLGGEKAEN QPALRGTAMH RFLEKLDFSM EDLANTYEAQ
     LSYELSHGFL TEEQKGLLQV SKLRAFMKSD LARRMKIADQ KGKLYREQAF VMGDDPEVFL
     SETEGNPELD IQDQVIVQGI MDAFFIEDDH IVLVDYKTDY VKTEQQLLKR YRKQMVLYKM
     ALERSFGLPV TEIYLYSFAL GRSVLV
//
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