ID A0A1H2TSZ1_9BACL Unreviewed; 649 AA.
AC A0A1H2TSZ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04489725_106118 {ECO:0000313|EMBL:SDW46992.1};
OS Alicyclobacillus hesperidum.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Alicyclobacillus.
OX NCBI_TaxID=89784 {ECO:0000313|EMBL:SDW46992.1, ECO:0000313|Proteomes:UP000182589};
RN [1] {ECO:0000313|Proteomes:UP000182589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12489 {ECO:0000313|Proteomes:UP000182589};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNOJ01000006; SDW46992.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2TSZ1; -.
DR STRING; 89784.SAMN04489725_106118; -.
DR Proteomes; UP000182589; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDW46992.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000182589};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 333..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 357..409
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 429..642
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 649 AA; 72009 MW; 82DF98067E0F2286 CRC64;
MERRTRVRFS LRYKIMAILF GAMLLIALLS DTLFYSTTRA QLLNNAVKQT ELLAQQIDLE
IAASRTGEAY IDNLLGNELR IASIAIEEQL PPRVADVTNS QLKRLAAQLG VSGITLFQPT
ADDIVGVRST DPREIGLSTK GMGKWYIAFR DLLAGRPQAS TYGMAEQNYW SGPFSNATSD
PSKVDKWGYY YDGRTDYIID PFYVSTSIPG YEQDVGVNTA IRHILDSDSD VLCIAVLNRT
FGQAPIRYSY HGTFWVDVAN EPVMYGEYKY RNPAVDVKAK NEALTSNRTV SVIDHVSGRK
VLKTFIPQSV HGTRYVVEVV TDYRAISSTL TILIHNLVIV SAVLLVATAL LSYLGADLIT
KPLRRITKAV DEIADRNFEA QLQVRRSDEI GVLADHVNEM SRKLVDYLRE LSMRERGKGM
DYLVMATHAL VHELGTPLAA IRQMSELLPR VQPGLNSKAV EILDRMHSAS AYANRVSREF
TNFLKHGRLT VKRADVLAIT REAAGMCRPM MESKHIQLVL DDRTAMAKVE LEIDADKVFA
AIVNLLKNAM DAIPESAPVR QVRLETKVEG EQLHVDVVDT GVGIPKERWD TIFMPYSSTK
KNGLGLGLTF SGLVAIAHGG TIEVVDSGPG GTRMRMCLPL IDRAVQGEA
//