ID A0A1H2TWT4_9FLAO Unreviewed; 1444 AA.
AC A0A1H2TWT4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SDW48280.1};
GN ORFNames=SAMN05444411_101829 {ECO:0000313|EMBL:SDW48280.1};
OS Lutibacter oricola.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Lutibacter.
OX NCBI_TaxID=762486 {ECO:0000313|EMBL:SDW48280.1, ECO:0000313|Proteomes:UP000199595};
RN [1] {ECO:0000313|EMBL:SDW48280.1, ECO:0000313|Proteomes:UP000199595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24956 {ECO:0000313|EMBL:SDW48280.1,
RC ECO:0000313|Proteomes:UP000199595};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; FNNJ01000001; SDW48280.1; -; Genomic_DNA.
DR STRING; 762486.SAMN05444411_101829; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000199595; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB/ACRD/ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199595};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 977..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1043..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1444 AA; 160494 MW; 8E5FF45AC7B49890 CRC64;
MINKIIDFSI NNKFIIGLLT LTIIGAGIWS MTQVPIDAVP DITNNQVQVI TQAPNLGTED
IEQIVTYPIE VAMSNLPNVQ EIRSISRFGL SVVTIVFDDD MGTYLPRQLV AEKLNEVKEQ
IPAGFGEPSM GPISTGLGEI YQYTLKVAPE FKDKYSIADL RSMQDWIVQR QMAMVEGVVE
VNAIGGKIKQ YEVAVDPNDL KAIGLTITDV FNALEANNQN TGGAYIEKNH QANFIRGEGL
VRSLEDIKKI TVKNVNNIPV TIGDIATVQF GAAIRYGALT QDGEGEVVGG LVMMLKGANS
NNVINNVKER MAQIEKSLPE GIIIQPLLDR SKLIGETTST VSNNLVEGAL IVIFVLIFLL
GNWRGGLIVA STIPLSLLFA FILMNVFDVW ANLMSLGAID FGIIVDGAVI IVESTVFLIT
SQLLKKKSLT AKERDKVASN ASKKMMNAAF FGQLIILIVF LPILALQGIE GKMFKPMAMT
FIFAMIGAMV LCLTYVPMMS ALVLRAPKNN KKSYGDKFVQ WVEDKYQPLL ERALQKGKWI
IGSAVVLFAI AVFIFTKMGG EFIPQLDEGD IAFHAILKPG SSLTETIETT TKIEQIVKAK
FPEVEKIVSR IGVAEIPTDP MPMDLADVFV ILKPKSEWTT TTSKDELIEM MKEAVEIVPG
VNYEFTQPIE MRFNELLEGV REDIAIKLYG EDIDILSQKA EEISKIIAGT EGIGDMKAEA
TTGLPQMTIN YNRNKLAQYG LHINTLNQTV QSAFAGGVAG VIFEGEKRFD LVVRLNSQNR
KDISDVQNLY INLPSGTQIP LREIADVSYK AGPMQISRDN TNRRTYVGVN VRGRDVKSLV
NEIKSKLDAQ LELPSGYFIR YGGAFENLER ASNRLQTVVP IALLLIFVLI YFALKSLPQT
LMIYIAIPMA TIGGVVALWL RDMPFSISAG VGFIVLFGVA VLNGLVMVSG LNELKEEGVT
NLKDRIIEGT KRRIRPIMLT AFTDVLGFLP MAISASAGAE VQRPLATVVI GGLLTSTLLT
LFVLPILYHW VENKSFKFIP NKKLVTATAV LLLMFGFSEQ SKAQQINNTL PEITLMDAVK
LSKRNYPLLK QKQLEITKQE QLKATAYDLG TTEVFTGGEE INGDEGVYTT IGIGQSDINI
FGVGSKRKLQ KQRVQLAQKA YQLSVLELEL EVKKAWSKCY QMKRNYNLYM ELDSIYSNFE
QAVALNYEVE AISRLEYSAA KNQAFQIQNK KMQAYSDYLI ALQQLNLWLV SDEIFTVSDE
FDSAIDLNIE KFNIENHPLY SMSQNIVDEA AANYKVAKAN NLPKFNLQGG LQKVEGISGF
YSYQAGISIP FLSGTNKAQI RSTKIDKEIA EANVLFKKQE VQSKFVQAKE NYIKWKNSWE
FYKNQVLPLT KEQKTGALLA YKEGEIEYTS FTQLIKEAIQ SELDAQTALI NYLESTFQLQ
YFNQ
//