ID A0A1H2VCT6_9BACL Unreviewed; 751 AA.
AC A0A1H2VCT6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=SAMN05444487_10554 {ECO:0000313|EMBL:SDW65744.1};
OS Marininema mesophilum.
OC Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
OC Marininema.
OX NCBI_TaxID=1048340 {ECO:0000313|EMBL:SDW65744.1, ECO:0000313|Proteomes:UP000198534};
RN [1] {ECO:0000313|EMBL:SDW65744.1, ECO:0000313|Proteomes:UP000198534}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45610 {ECO:0000313|EMBL:SDW65744.1,
RC ECO:0000313|Proteomes:UP000198534};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR EMBL; FNNQ01000005; SDW65744.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2VCT6; -.
DR STRING; 1048340.SAMN05444487_10554; -.
DR OrthoDB; 9803432at2; -.
DR Proteomes; UP000198534; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000198534}.
FT DOMAIN 155..246
FT /note="RecD helicase-like helix-hairpin-helix"
FT /evidence="ECO:0000259|Pfam:PF14490"
FT DOMAIN 588..656
FT /note="RecD-like DNA helicase SH3"
FT /evidence="ECO:0000259|Pfam:PF18335"
FT DOMAIN 673..721
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13538"
FT BINDING 364..368
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 751 AA; 84635 MW; 8067315162897238 CRC64;
MEQPGLDLFQ ESYLKGSFVQ EIYYNEESHY GVFLLRVIEA TEELDTDEVT VVGSMMRPHP
DETVICYGEW KDHPRYGKQY QARMVKKELP RSREAVAKYL ASGLFPGVGK KTAEKIVDHL
GTDALTRAAD DPGLLAEVPG LTDARAQTIA DSLREHHSLE QALVYLYQFG MGPATALKVV
QAFKGATLEV VKKNPYRMID EVEGVGFRRA DEIARQTGMA LDAPERFQAA AIYALREASL
SHGHVFVTEK ELMEGIDQLL APQGEEWFPA EKRKLLIAKM AEEERLIEDH EKYYLPSLFW
AEHGLAMRVR SMLEGTTEPT PAHELFKAVG EVEEELKVAY AERQREAMTT AVDAPFMILT
GGPGTGKTTV IRGICHLFAR LEECSIDPAD YENSEKPYPI RLVAPTGRAA KRMSEATGIP
ATTIHRLLGW RGDFFERDAD HPIEGSLLIV DEVSMLDVWL ANQLLRAVPK GMKVVLVGDD
DQLPSVGPGK VLQHLLQVKA IPRVQLVEIY RQEGGSSIIH LAHALKKGEV PHDLTEPKPD
RRFFSCRRNQ ALHIILQTYM NALERGYTVF DVQVMAPMYK GLAGVNRINE AIQEAVNPPE
EGKRETAWGE AVFRHGDKVL QLSNHPEHPV YNGDMGHVSA LEPDARNDDP VLWVQFDRQE
IPYKRSQLNQ LALAYACSVH KAQGSEFEIV IFPVLMSYRR MLQRNLIYTG ITRAKSYLIL
CGEKEALSLG VKSREREERN SQLTELIEME W
//
