ID   A0A1H2WDX8_9BACI        Unreviewed;       377 AA.
AC   A0A1H2WDX8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=S-(Hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase {ECO:0000313|EMBL:SDW78474.1};
GN   ORFNames=SAMN05421781_2373 {ECO:0000313|EMBL:SDW78474.1};
OS   Marinococcus luteus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Marinococcus.
OX   NCBI_TaxID=1122204 {ECO:0000313|EMBL:SDW78474.1, ECO:0000313|Proteomes:UP000199488};
RN   [1] {ECO:0000313|EMBL:SDW78474.1, ECO:0000313|Proteomes:UP000199488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23126 {ECO:0000313|EMBL:SDW78474.1,
RC   ECO:0000313|Proteomes:UP000199488};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; FNNC01000005; SDW78474.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2WDX8; -.
DR   STRING; 1122204.SAMN05421781_2373; -.
DR   OrthoDB; 9769198at2; -.
DR   Proteomes; UP000199488; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199488};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          26..138
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          188..257
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   377 AA;  41298 MW;  58CE1F5E9C3F57B7 CRC64;
     MKAVTIQGKE HMEVKEVADP KIERSDDMIV RITASGICGS DLHLYKGGIP TPEDYVVGHE
     PMGIVEEVGP DVKTLKKGDR VVIPFNIGCG ECYYCTHQME SQCDNSNPHA EMGGLFGFSE
     DFGNFPGGQA EYLRVPYADF TSFKVPEDSE LKDESVLFLS DVVPTAFWSI ENSGATYGDT
     IIILGCGPIG LMAQKFAWMK GASRVIAVDQ VPHRLEHARR TNNVETYNFS ETKEIGKLLH
     QDTKGGADVV VDCVGMDGTV PPDTTFGSES DNQFGTISPI VTASQSVKKN GVVQLTGVYG
     TEANNFPIGD FFTRNVALTM GQAPVIHMMP SLYRMIENKL FDPTDIITHP IPLEDAAEGY
     RIFDEKEDGN IKVILKP
//