ID   A0A1H2WSP9_9FIRM        Unreviewed;       467 AA.
AC   A0A1H2WSP9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Alanine or glycine:cation symporter, AGCS family {ECO:0000313|EMBL:SDW83577.1};
GN   ORFNames=SAMN05660923_01333 {ECO:0000313|EMBL:SDW83577.1};
OS   Tepidimicrobium xylanilyticum.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Tepidimicrobiaceae;
OC   Tepidimicrobium.
OX   NCBI_TaxID=1123352 {ECO:0000313|EMBL:SDW83577.1, ECO:0000313|Proteomes:UP000198828};
RN   [1] {ECO:0000313|EMBL:SDW83577.1, ECO:0000313|Proteomes:UP000198828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23310 {ECO:0000313|EMBL:SDW83577.1,
RC   ECO:0000313|Proteomes:UP000198828};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; FNNG01000004; SDW83577.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2WSP9; -.
DR   OrthoDB; 9804874at2; -.
DR   Proteomes; UP000198828; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF14; SODIUM_AMINO ACID (ALANINE) SYMPORTER-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198828};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        70..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        98..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        149..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        302..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        386..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        416..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   467 AA;  50030 MW;  0AB6314DBD59989C CRC64;
     MHALERIVSF VNGILWDYVL VIGLVGIGIF LSIMLGFPQI KKFGTAAKKV FGGIFNKEEN
     KEGSMSSFQA LATSIAAQIG TGNVAGVATA IASGGPGAVF WMWMSAIFGM ATIFVEATLA
     QKYRETDVDG QLVGGPAYYI KNGLKSKGLA TFFAIALIIA LGFIGNMVQS NSIADAISRA
     FNIPNIAIGI AIAIIAGLIF IGGMSRIAKF AEMVVPVMAV IYILGTVTVL ILFRSSIIPT
     LKSIIVGAFN PQAVLGGAVG IGIKQAVRYG VARGLFSNEA GMGSTPNSHA VADVEHPAEQ
     GFSAMIAVFI DTILVCTATA LVILVTGADK LGLAGVAVTQ RGFGIAFGPI GERFLAICLT
     FFAFTTVIGW YYFGENNLRF LFKGKIAIRI YQVIVLIFIV LGSYQKVDLV WNVADMFNGI
     MVIPNLIALF LLYKESKNML RDYDSQIAKG EKLYFNYEFE KQTNSRG
//