ID A0A1H2X657_9FIRM Unreviewed; 460 AA.
AC A0A1H2X657;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=L-cystine uptake protein TcyP {ECO:0000256|ARBA:ARBA00022031};
DE AltName: Full=Transporter of cystine TcyP {ECO:0000256|ARBA:ARBA00031293};
GN ORFNames=SAMN05660923_01351 {ECO:0000313|EMBL:SDW88236.1};
OS Tepidimicrobium xylanilyticum.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Tepidimicrobiaceae;
OC Tepidimicrobium.
OX NCBI_TaxID=1123352 {ECO:0000313|EMBL:SDW88236.1, ECO:0000313|Proteomes:UP000198828};
RN [1] {ECO:0000313|EMBL:SDW88236.1, ECO:0000313|Proteomes:UP000198828}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23310 {ECO:0000313|EMBL:SDW88236.1,
RC ECO:0000313|Proteomes:UP000198828};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|ARBA:ARBA00006148}.
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DR EMBL; FNNG01000005; SDW88236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H2X657; -.
DR OrthoDB; 7778689at2; -.
DR Proteomes; UP000198828; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865:SF5; L-CYSTINE TRANSPORTER TCYP; 1.
DR PANTHER; PTHR42865; PROTON/GLUTAMATE-ASPARTATE SYMPORTER; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198828};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 460 AA; 48857 MW; 22774DA0322407BD CRC64;
MNGTFYIIIN ITIMAVLIYI LLYLRRKRVS FTVRVMLALI CGIAFGAALQ LIYGAGSQIV
NSSNTWFDVI GTGYIRLLRM IVIPLIFISI VNAIISQDSK NLGKMAAQII AILIITTAIS
AFVGAGVAKA FNLTSEGLVA GEKEQQAGLG LEQRLEDFQS KPIQQQLIEI IPINPFYAMT
GQGSSATLSV VFFAAVVALA AIGIRKSKPE AAESFVNLIN ILHAIVMRMV TMVLRLTPYG
VLALMTRFVS NSDFSEIARL IQFVIASYVA LAIMFVIHMA ILMVFGLNPI SYVRKSAPVL
MFAFSSRSSA GTLPLTINNQ VRNLGVADGH ANLAGSLGTS IGQNGCAGIY PAMLAVMIAP
TVGINPMAPA FLIKLIIITA LASFGIAGVG GGATFAALTV LSAMGLPVGL VGLLIAIEPL
IDMGRTLLNV SGSMLAGVLS SKFMGELDTE IYNSRKIEEV
//
