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Database: UniProt
Entry: A0A1H2X706_9BACI
LinkDB: A0A1H2X706_9BACI
Original site: A0A1H2X706_9BACI 
ID   A0A1H2X706_9BACI        Unreviewed;       196 AA.
AC   A0A1H2X706;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Ribonuclease H {ECO:0000256|ARBA:ARBA00012180, ECO:0000256|PIRNR:PIRNR037839};
DE            EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180, ECO:0000256|PIRNR:PIRNR037839};
GN   ORFNames=SAMN05421781_2688 {ECO:0000313|EMBL:SDW88692.1};
OS   Marinococcus luteus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Marinococcus.
OX   NCBI_TaxID=1122204 {ECO:0000313|EMBL:SDW88692.1, ECO:0000313|Proteomes:UP000199488};
RN   [1] {ECO:0000313|EMBL:SDW88692.1, ECO:0000313|Proteomes:UP000199488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23126 {ECO:0000313|EMBL:SDW88692.1,
RC   ECO:0000313|Proteomes:UP000199488};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA
CC       hybrids. {ECO:0000256|PIRNR:PIRNR037839}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037839};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037839-1};
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037839-1};
CC       Note=Binds 2 metal ions per subunit. Manganese or magnesium.
CC       {ECO:0000256|PIRSR:PIRSR037839-1};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037839}.
CC   -!- SIMILARITY: Belongs to the RNase H family.
CC       {ECO:0000256|ARBA:ARBA00005300, ECO:0000256|PIRNR:PIRNR037839}.
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DR   EMBL; FNNC01000006; SDW88692.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H2X706; -.
DR   STRING; 1122204.SAMN05421781_2688; -.
DR   OrthoDB; 9811552at2; -.
DR   Proteomes; UP000199488; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR   InterPro; IPR009027; Ribosomal_bL9/RNase_H1_N.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   InterPro; IPR017290; RNase_H_bac.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR   PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   PIRSF; PIRSF037839; Ribonuclease_H; 1.
DR   SUPFAM; SSF55658; L9 N-domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037839};
KW   Endonuclease {ECO:0000256|PIRNR:PIRNR037839};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR037839};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR037839, ECO:0000256|PIRSR:PIRSR037839-1};
KW   Manganese {ECO:0000256|PIRSR:PIRSR037839-1};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR037839,
KW   ECO:0000256|PIRSR:PIRSR037839-1}; Nuclease {ECO:0000256|PIRNR:PIRNR037839};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199488}.
FT   DOMAIN          62..196
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   BINDING         71
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
FT   BINDING         109
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
FT   BINDING         132
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
FT   BINDING         192
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
SQ   SEQUENCE   196 AA;  22412 MW;  347499CA09B16195 CRC64;
     MAKKKWYVVW KGKKPGIYST WAECEKQVKG FKGAKFKSFP SYEEAEAAFN GSGGKPETEN
     GSYITESISV DAGSHGNPGP VEYRGVYTKT EEIVFAHPGF KKGTNNMAEF LGIVHALRYL
     KEQESPMPVY SDSATAIGWV EKKKANSTLV EDAESREIWE DIRRAEKWLK EHTWENPIYK
     WDTKNWGEIK ADYQRK
//
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