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Database: UniProt
Entry: A0A1H3A651_9GAMM
LinkDB: A0A1H3A651_9GAMM
Original site: A0A1H3A651_9GAMM 
ID   A0A1H3A651_9GAMM        Unreviewed;       241 AA.
AC   A0A1H3A651;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ {ECO:0000256|RuleBase:RU362024};
DE            EC=2.1.1.200 {ECO:0000256|RuleBase:RU362024};
DE   AltName: Full=tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase {ECO:0000256|RuleBase:RU362024};
DE   AltName: Full=tRNA Cm32/Um32 methyltransferase {ECO:0000256|RuleBase:RU362024};
GN   Name=trmJ {ECO:0000256|RuleBase:RU362024};
GN   ORFNames=SAMN05443545_104371 {ECO:0000313|EMBL:SDX25210.1};
OS   Aidingimonas halophila.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Aidingimonas.
OX   NCBI_TaxID=574349 {ECO:0000313|EMBL:SDX25210.1, ECO:0000313|Proteomes:UP000198500};
RN   [1] {ECO:0000313|EMBL:SDX25210.1, ECO:0000313|Proteomes:UP000198500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19219 {ECO:0000313|EMBL:SDX25210.1,
RC   ECO:0000313|Proteomes:UP000198500};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or
CC       2'O-methylated uridine (Um32) at position 32 in tRNA.
CC       {ECO:0000256|RuleBase:RU362024}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-
CC         methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42936, Rhea:RHEA-COMP:10107, Rhea:RHEA-COMP:10290,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.200;
CC         Evidence={ECO:0000256|RuleBase:RU362024};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-
CC         methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42932, Rhea:RHEA-COMP:10288, Rhea:RHEA-COMP:10289,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.200;
CC         Evidence={ECO:0000256|RuleBase:RU362024};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362024}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362024}.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family.
CC       {ECO:0000256|ARBA:ARBA00007228}.
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DR   EMBL; FNNI01000004; SDX25210.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3A651; -.
DR   STRING; 574349.SAMN05443545_104371; -.
DR   OrthoDB; 9806346at2; -.
DR   Proteomes; UP000198500; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:GOC.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd18093; SpoU-like_TrmJ; 1.
DR   Gene3D; 1.10.8.590; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR004384; RNA_MeTrfase_TrmJ/LasT.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   NCBIfam; TIGR00050; rRNA_methyl_1; 1.
DR   PANTHER; PTHR42786:SF2; TRNA (CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ; 1.
DR   PANTHER; PTHR42786; TRNA/RRNA METHYLTRANSFERASE; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   PIRSF; PIRSF004808; LasT; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU362024};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|RuleBase:RU362024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198500};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU362024};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDX25210.1};
KW   tRNA processing {ECO:0000256|RuleBase:RU362024}.
FT   DOMAIN          5..155
FT                   /note="tRNA/rRNA methyltransferase SpoU type"
FT                   /evidence="ECO:0000259|Pfam:PF00588"
SQ   SEQUENCE   241 AA;  26726 MW;  5D499ED2FA73239E CRC64;
     MLSNIRIVLV QTFHPGNIGQ AARAMKTMGL TDLVLVTPRR FPDHEADRLA AGAEDVVADA
     RVVDTLSEAV SDCVQVVGAS ARLRSQPLPH YDEPDVMAQT LVELAAEDPV ALVFGRERFG
     LTNDEIQCCS HQVSIPANPD YGILNLSQAV QVLAYEVFRA WRQRPDSGYQ TPRPSTGPLP
     TRQQLDYFHA HLSRVMHASG FLTQPHARTE QQLQALFNRA QPNRKELSLL RGLLNSLEES
     L
//
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