ID   A0A1H3AHQ4_9ACTN        Unreviewed;      1084 AA.
AC   A0A1H3AHQ4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Adenylate and Guanylate cyclase catalytic domain-containing protein {ECO:0000313|EMBL:SDX29206.1};
GN   ORFNames=SAMN05660209_00056 {ECO:0000313|EMBL:SDX29206.1};
OS   Geodermatophilus africanus.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=1137993 {ECO:0000313|EMBL:SDX29206.1, ECO:0000313|Proteomes:UP000198921};
RN   [1] {ECO:0000313|EMBL:SDX29206.1, ECO:0000313|Proteomes:UP000198921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45422 {ECO:0000313|EMBL:SDX29206.1,
RC   ECO:0000313|Proteomes:UP000198921};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNOT01000001; SDX29206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3AHQ4; -.
DR   STRING; 1137993.SAMN05660209_00056; -.
DR   OrthoDB; 3691954at2; -.
DR   Proteomes; UP000198921; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          74..208
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1084 AA;  116120 MW;  6A709E46B8053739 CRC64;
     MTGLALSAET RLARLLERLL TGAEASLAAG DLEPARATAE EVRAVDPDNR RAALVLKQVA
     ARQLHPSGER ALMTLLFSDL VGPTVLSEQV EPEQLRDLFA VYRAAAREAV HRYGGHLMHY
     SGDGILAGFG HPEPHEDDAR RAVLAGLDLV TAMRDARAEL DRRFGVAPEV RVGLHTGRVV
     VTDLSDDGAV AERDSIVGLV PNLAARIQQA ADPGTVVISD VTQQLVDADF FLHSLGERRL
     KGISRPVEVF AVDRPRYAAA RFQAERYRKA GLVGRDEQRT RLLAAWDAVR QGTAPTAATF
     LVAGEAGIGK SRLVAEVLDR VEASGGRVLG AACLPYYANV SLWPIARLLE RLMGRSGEDT
     DRLGWLVSNL DALGVDPARA VPFLGPLIGV PATAEYPAPE LDPSAVLDQT LDLLVDWLAA
     GAGRRPHLFV VEDLHWADSS TLGLLERVAE RHPAGLLTVA TVRDASVVPW RDAVGVVELG
     RLDGPAAHRL VDNLAAGQRL DGGARAAIIE HAEGIPLFIE ELTRSRIDAR HPDPIPLRLQ
     ELLTWRLKAP GVDLRVVQTA ATIGPTFDPA TVAAVVGDAD LVAEQLPVLA DAGIVEPVGL
     AAGAFRFRHA LMRDAAYETQ VLDVRRRTHA RVAEALAARG AQPALVAQHL DLAGAAEQAA
     ARYLEAARVE QGRGAHPEAT KLISRALELL ETLPESDDRA MGQLTARMLH GLSVSSMQGY
     ASPAVEADHR RAQELAARLG RPEVLPALIA IWAYWLTSGR LTTARGVLDQ LTAIVREPAF
     ASFEPEVAVL AGIHDFHRGH LVSAQAHLER AEAGFAARPA DQRVSLLWPL PDDPISVSAS
     VLAGVSAARG ELDEAERWQE EALRRAEADG SPRGPVSLVF VEIYVALIRY FLGDDAGASR
     AGTEAVAIGE EHGLAFRSAW GAAWAATGTP GGPPDREYLE RALAALELMG WLTFLASHLA
     RLARLDAAAG DVDRAEAHLA EAFAAAQRSG EDLHLPELLR QRAALTLARG GDAARAVADL
     TEALRIATAQ GARVSRLRAA LDLARLPAPS RPAHWRRLLE EARADMPPSF RGDEAAAADD
     LLRD
//