ID A0A1H3E299_9ACTN Unreviewed; 561 AA.
AC A0A1H3E299;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SAMN05661080_00955 {ECO:0000313|EMBL:SDX72039.1};
OS Modestobacter sp. DSM 44400.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=1550230 {ECO:0000313|EMBL:SDX72039.1, ECO:0000313|Proteomes:UP000199500};
RN [1] {ECO:0000313|EMBL:SDX72039.1, ECO:0000313|Proteomes:UP000199500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44400 {ECO:0000313|EMBL:SDX72039.1,
RC ECO:0000313|Proteomes:UP000199500};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; FNOZ01000004; SDX72039.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3E299; -.
DR STRING; 1550230.SAMN05661080_00955; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000199500; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199500}.
FT DOMAIN 190..344
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 399..545
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 561 AA; 62331 MW; B5E4B4CA839DEE5B CRC64;
MSDGPLIVQS DKTLLLEVDH PLSKECRAAI APFAELERSP EHVHTYRVTP LALWNARAAG
HDAEQVVDAL VRYSRYPVPH ALLVDIADTM DRYGRLTLAN NPVHGLVLSS TDRAVLEEVV
RSKRVGPMLG ARIDTDSVVV HPSERGRLKQ ALLKIGWPAE DLAGYVDGQA HQIELDQADW
HLRDYQQQAV DGFWAGGSGV VVLPCGAGKT LVGAAAMAEA KATTLILVTN TVAGRQWKRE
LIARTTLTEE EIGEYSGERK EIRPVTIATY QVITTRRKGE YRHLDLFDAQ DWGLIIYDEV
HLLPAPIFRL TADLQSRRRL GLTATLVRED GREDDVFSLI GPKRYDAPWR DIEAQGYIAP
AECIEVRVSL DDEERMTYAV AEPEERYRIA ATAQSKLPVI RRVLERHPDE PSLVIGAYLD
QLEELGAALD APVIQGSTTN KERERLYQAF RTGEIRTLVV SKVANFSIDL PEAAVAVQVS
GTFGSRQEEA QRLGRVLRPK ADGRQAHFYT VVSRDTLDSE YAAHRQRFLA EQGYAYTIVD
AADLAGPGEV NGPDWVDEPA D
//
